Virology, Epidemiology, Pathogenesis, and Control of COVID-19.
Yuefei Jin,Haiyan Yang,Wangquan Ji,Weidong Wu,Shuaiyin Chen,Weiguo Zhang,Weiguo Zhang,Guangcai Duan +7 more
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TLDR
The present understanding of COVID-19 is detailed and the current state of development of measures are introduced in this review to provide a comprehensive summary to public health authorities and potential readers worldwide.Abstract:
The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. To provide a comprehensive summary to public health authorities and potential readers worldwide, we detail the present understanding of COVID-19 and introduce the current state of development of measures in this review.read more
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Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis.
TL;DR: Men had higher disease severity than premenopausal women, while the differences disappeared between post menopausal women and men, and these findings support aggressive treatment for the poor prognosis of postmenopausalWomen in clinical practice.
Journal ArticleDOI
Understanding COVID-19: From Origin to Potential Therapeutics.
Muhammad Moazzam,Muhammad Imran Sajid,Muhammad Imran Sajid,Hamza Shahid,Jahanzaib Butt,Irfan Bashir,Muhammad Jamshaid,Amir Nasrolahi Shirazi,Rakesh Tiwari +8 more
TL;DR: This review has compiled the up to date information about the origins, evolution, epidemiology, and pathogenesis of this disease and a detailed account of clinical trials of vaccines and other therapeutics currently in progress has been delineated.
Journal ArticleDOI
The impact of individual lifestyle and status on the acquisition of COVID-19: A case-Control study.
Chang Gao,Zhi Zhao,Fengyuan Li,Jialin Liu,Hongyang Xu,Yuanying Zeng,Ling Juan Yang,Jiahao Chen,Xiaoting Lu,Can Wang,Qiang Guo +10 more
TL;DR: Individual lifestyle behaviors and health status can affect the occurrence of COVID-19 and low-dose alcohol intake, hand hygiene, and fruits intake (daily) were significantly associated with a decrease in morbidity.
Journal ArticleDOI
An Aspect of Kumbh Mela Massive Gathering and COVID-19.
Sayed A Quadri,Prasad R. Padala +1 more
TL;DR: In this article, the authors dwell in the religious and social background of Kumbh Mela massive gathering, as well as the ritualistic practices that could potentially entail public health risks in the current situation.
Journal ArticleDOI
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
Yajuan Jiao,Ning Kong,Hua Wang,Dage Sun,Sujie Dong,Xiaoyong Chen,Hao Zheng,Wu Tong,Hai Yu,Lingxue Yu,Yaowei Huang,Huan Wang,Baokun Sui,Ling Zhao,Ying Liao,Wen Zhang,Guangzhi Tong,Tongling Shan +17 more
TL;DR: In this article, the authors showed that the host protein, PABPC4, could be regulated by transcription factor SP1 and broadly inhibited the replication of CoVs by targeting the nucleocapsid (N) protein through the autophagosomes for degradation.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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