Virulence factors of the Mycobacterium tuberculosis complex
Marina Andrea Forrellad,Laura Inés Klepp,Andrea Gioffré,Julia Veronica Sabio Y Garcia,Héctor R. Morbidoni,María de la Paz Santangelo,Ángel Adrián Cataldi,Fabiana Bigi +7 more
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TLDR
The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection.Abstract:
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
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Host evasion and exploitation schemes of Mycobacterium tuberculosis
TL;DR: Tuberculosis is a near-perfect paradigm of a host-pathogen relationship, and that may be the challenge to the development of new therapies for its eradication.
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Immune Response to Mycobacterium tuberculosis: A Narrative Review.
TL;DR: This narrative mini-review summarizes the various immunologic mechanisms which modulate the individual ability to fight Mtb infection taking in account the major host and pathogen determinants in the susceptibility to tuberculosis.
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Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS.
Nicole A. Kruh-Garcia,Lisa M. Wolfe,Lelia H. Chaisson,William Worodria,Payam Nahid,Jeffrey S. Schorey,J. Lucian Davis,Karen M. Dobos +7 more
TL;DR: Development of targeted proteomics assays employing multiplexed multiple reaction monitoring mass spectrometry (MRM-MS) is described in order to allow us to follow those proteins previously identified by western blot or shotguns, and enhance biomarker discovery to include detection of Mtb proteins in human serum exosomes.
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Cutaneous tuberculosis: epidemiologic, etiopathogenic and clinical aspects - Part I
Josemir Belo dos Santos,Ana Roberta Figueiredo,Cláudia Elise Ferraz,Márcia Helena de Oliveira,Perla Gomes da Silva,Vanessa Lucília Silveira de Medeiros +5 more
TL;DR: The current knowledge about this disease's physiopathology and immunology is revised as well as detailing the possible clinical presentations.
References
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Stewart T. Cole,Roland Brosch,Julian Parkhill,Thierry Garnier,Carol Churcher,David Harris,Stephen V. Gordon,Karin Eiglmeier,S. Gas,Clifton E. Barry,Fredj Tekaia,K. Badcock,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Anders Krogh,J. McLean,Sharon Moule,Lee Murphy,K. Oliver,J. Osborne,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,S. Rutter,K. Seeger,Jason Skelton,Rob Squares,S. Squares,John Sulston,K. Taylor,Sally Whitehead,Bart Barrell +41 more
TL;DR: The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions.
Journal ArticleDOI
Superoxide Radical and Superoxide Dismutases
TL;DR: O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH..
Journal ArticleDOI
Genes required for mycobacterial growth defined by high density mutagenesis
TL;DR: The use of transposon site hybridization (TraSH) is described to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth, suggesting that the minimal gene set required for survival varies greatly between organisms with different evolutionary histories.
Journal ArticleDOI
Massive gene decay in the leprosy bacillus
Stewart T. Cole,Karin Eiglmeier,Julian Parkhill,Keith D. James,Nicholas R. Thomson,Paul R. Wheeler,Nadine Honoré,Thierry Garnier,Carol Churcher,David Harris,Karen Mungall,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Stephanie Duthoy,Theresa Feltwell,Audrey Fraser,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Céline Lacroix,J. Maclean,Sharon Moule,Lee Murphy,K. Oliver,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,S. Rutter,K. Seeger,Sylvie Simon,Mark Simmonds,Jason Skelton,Rob Squares,S. Squares,K. Stevens,K. Taylor,Sally Whitehead,J. R. Woodward,Bart Barrell +43 more
TL;DR: Comparing the 3.27-megabase genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis provides clear explanations for these properties and reveals an extreme case of reductive evolution.
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