Journal ArticleDOI
Visible-Light-Triggered Reactive-Oxygen-Species-Mediated Antibacterial Activity of Peroxidase-Mimic CuO Nanorods
Md. Nurul Karim,Mandeep Singh,Pabudi Weerathunge,Pengju Bian,Rongkun Zheng,Chaitali Dekiwadia,Taimur Ahmed,Sumeet Walia,Enrico Della Gaspera,Sanjay Singh,Rajesh Ramanathan,Vipul Bansal +11 more
- Vol. 1, Iss: 4, pp 1694-1704
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TLDR
This work shows that the favorable band structure of a CuO-nanorod-based NanoZyme catalyst (band gap of 1.44 eV) allows visible light to control the antibacterial activity and remarkably accelerating the production of reactive oxygen species (ROS) by 20 times.Abstract:
The rapid emergence of antibiotic-resistant bacterial strains warrants new strategies for infection control. NanoZymes are emerging as a new class of catalytic nanomaterials that mimic the biological action of natural enzymes. The development of photoactive NanoZymes offers a promising avenue to use light as a “trigger” to modulate the bacterial activity. Visible light activity is particularly desirable because it contributes to 44% of the total solar energy. Here we show that the favorable band structure of a CuO-nanorod-based NanoZyme catalyst (band gap of 1.44 eV) allows visible light to control the antibacterial activity. Photomodulation of the peroxidase-mimic activity of CuO nanorods enhances its affinity to H2O2, thereby remarkably accelerating the production of reactive oxygen species (ROS) by 20 times. This photoinduced NanoZyme-mediated ROS production catalyzes physical damage to the bacterial cells, thereby enhancing the antibacterial performance against Gram-negative-indicator bacteria Escheri...read more
Citations
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Journal ArticleDOI
Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction.
TL;DR: This study reports on the construction of an efficient biomimetic dual inorganic nanozyme‐based nanoplatform, which triggers cascade catalytic reactions for tumor microenvironment responsive nanocatalytic tumor therapy based on ultrasmall Au and Fe3O4 NPs coloaded dendritic mesoporous silica NPs.
Journal ArticleDOI
Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives.
TL;DR: Antibiotic‐free antibacterial strategies enabled by advanced nanomaterials are presented and practical antibacterial applications employing these antibiotic‐free strategies are introduced.
Journal ArticleDOI
Ultrasensitive Colorimetric Detection of Murine Norovirus Using NanoZyme Aptasensor.
Pabudi Weerathunge,Rajesh Ramanathan,Valeria A. Torok,Kate R. Hodgson,Yun Xu,Royston Goodacre,Bijay Kumar Behera,Vipul Bansal +7 more
TL;DR: This approach combines the enzyme-mimic catalytic activity of gold nanoparticles with high target specificity of an MNV aptamer to create sensor probes that produce a blue color in the presence of this norovirus, such that the color intensity provides the virus concentrations.
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Antimicrobial Metal Nanomaterials: From Passive to Stimuli-Activated Applications.
Samuel Cheeseman,Andrew J. Christofferson,Rashad Kariuki,Daniel Cozzolino,Torben Daeneke,Russell J. Crawford,Vi Khanh Truong,James Chapman,Aaron Elbourne +8 more
TL;DR: This review aims to summarize the currently available research and provide future scope for the development of metal nanomaterial‐based antimicrobial technologies, particularly those that can be activated through externally applied stimuli.
Journal ArticleDOI
A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications
TL;DR: In this paper, the authors dig into the characteristics and intrinsic properties of metal and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy.
References
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Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
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Journal ArticleDOI
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