Journal ArticleDOI
Vitamin B12 Deficiency
Ralph Green,Lindsay H. Allen,Anne-Lise Bjørke-Monsen,Alex Brito,Jean-Louis Guéant,Joshua W. Miller,Anne M. Molloy,Ebba Nexo,Sally P. Stabler,Ban Hock Toh,Per Magne Ueland,Chittaranjan S. Yajnik +11 more
- Vol. 3, Iss: 1, pp 17040-17040
TLDR
Vitamin B12 deficiency causes reversible megaloblastic anemia, demyelinating disease, or both; current assays have insufficient sensitivity and specificity; methylmalonic acid levels are useful to confirm diagnosis.Abstract:
Vitamin B12 deficiency causes reversible megaloblastic anemia, demyelinating disease, or both. Current assays have insufficient sensitivity and specificity; methylmalonic acid levels are useful to confirm diagnosis. Parenteral or high-dose oral vitamin B12 is effective therapy.read more
Citations
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Journal ArticleDOI
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
Peter Malfertheiner,Francis Mégraud,Colm O'Morain,Javier P. Gisbert,Ernst J. Kuipers,A. T. R. Axon,Franco Bazzoli,Antonio Gasbarrini,John Atherton,David Y. Graham,Richard H. Hunt,Paul Moayyedi,Theodore Rokkas,Massimo Rugge,Michael Selgrad,Sebastian Suerbaum,Kentaro Sugano,Emad M. El-Omar +17 more
TL;DR: This fifth edition of the Maastricht Consensus Report describes how experts from 24 countries examined new data related to H. pylori infection in the various clinical scenarios and provided recommendations on the basis of the best available evidence and relevance.
Journal ArticleDOI
Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.
TL;DR: A 34-year-old woman with an initial complaint of progressive fatigue, weakness and numbness in her limbs and disturbed gait is described, revealing appearance of anemia, ataxia, decrease of superficial and deep sense, and positive Babinski's sign.
Journal ArticleDOI
ESPEN guideline: Clinical nutrition in inflammatory bowel disease
Alastair Forbes,Johanna C. Escher,Xavier Hébuterne,Stanislaw Klek,Zeljko Krznaric,Stéphane M. Schneider,Raanan Shamir,Kalina Stardelova,Nicolette J. Wierdsma,Anthony E. Wiskin,Stephan C. Bischoff +10 more
TL;DR: The recommended perioperative management of patients with IBD undergoing surgery accords with general ESPEN guidance for patients having abdominal surgery, and primary therapy using nutrition to treat IBD is moderately well supported in Crohn's disease.
Journal ArticleDOI
Elevated Plasma Vitamin B12 Concentrations Are Independent Predictors of In-Hospital Mortality in Adult Patients at Nutritional Risk
Silvia Cappello,Emanuele Cereda,Mariangela Rondanelli,Catherine Klersy,Barbara Cameletti,Riccardo Albertini,Daniela Magno,Marilisa Caraccia,Annalisa Turri,Riccardo Caccialanza +9 more
TL;DR: Although the underlying mechanisms are still unknown and any cause-effect relation cannot be inferred, clinicians should be aware of the potential negative impact of high vitamin B12 concentrations in hospitalized patients at nutritional risk and avoid inappropriate vitamin supplementation.
Journal ArticleDOI
Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries
TL;DR: In this paper, the authors outline definitions and classifications of anemia, describe the biological mechanisms through which anemia develops, and review the variety of conditions that contribute to anemia development.
References
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Journal ArticleDOI
Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis
John Lindenbaum,E. B. Healton,D. G. Savage,J C Brust,T J Garrett,E R Podell,P D Marcell,Sally P. Stabler,Robert H. Allen +8 more
TL;DR: It is concluded that neuropsychiatric disorders due to cobalamin deficiency occur commonly in the absence of anemia or an elevated mean cell volume and that measurements of serum methylmalonic acid and total homocysteine both before and after treatment are useful in the diagnosis of these patients.
Journal ArticleDOI
Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion
Helga Refsum,A. David Smith,Per Magne Ueland,Ebba Nexo,Robert Clarke,Joseph McPartlin,Carole Johnston,Frode Engbaek,Jörn Schneede,Catherine McPartlin,John M. Scott +10 more
TL;DR: The purpose of this review is to provide an international expert opinion on the practical aspects of total homocysteine determinations in clinical practice and in the research setting and on the relevance of total Homocystinuria measurements as diagnostic or screening tests in several target populations.
Journal ArticleDOI
Neurologic aspects of cobalamin deficiency.
TL;DR: A wide variety of neurologic symptoms and signs were encountered, however, including ataxia, loss of cutaneous sensation, muscle weakness, diminished or hyperactive reflexes, spasticity, urinary or fecal incontinence, orthostatic hypotension, Loss of vision, dementia, psychoses, and disturbances of mood.
Journal ArticleDOI
Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.
Jane Durga,Martin P.J. van Boxtel,Evert G. Schouten,Frans J. Kok,Jelle Jolles,Martijn B. Katan,Petra Verhoef +6 more
TL;DR: Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age, particularly in memory and sensorimotor speed.