Wound healing - A literature review.
Ana Cristina Gonzalez,Tila Fortuna Costa,Zilton A. Andrade,Alena Ribeiro Alves Peixoto Medrado +3 more
TLDR
The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.Abstract:
Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.read more
Citations
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Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin.
TL;DR: The adhesive antibacterial and conductive GT-DA/chitosan/CNT hydrogels showed great potential as multifunctional bioactive dressings for the treatment of infected wounds.
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Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Azar Nourian Dehkordi,Fatemeh Mirahmadi Babaheydari,Mohammad Chehelgerdi,Shiva Raeisi Dehkordi +3 more
TL;DR: This review presents some sets of the data published on using embryonic stem cells, induced pluripotentstem cells, and adult stem cells in healing wounds and discusses the different angles whereby these cells can contribute to their unique features and show the current drawbacks.
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ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
TL;DR: Newly emerging roles of ICAM‐1 in epithelial injury‐resolution responses, as well as immune cell effector function in inflammation and tumorigenesis are focused on.
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Advanced Hydrogels as Wound Dressings.
TL;DR: This review focuses on the most recent developments in the field of hydrogel-based skin substitutes for skin replacement, and discusses the synthesis, fabrication, and biomedical application of novel “smart” hydrogels.
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Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends
Federica Paladini,Mauro Pollini +1 more
TL;DR: This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.
References
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Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
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Wound Healing--Aiming for Perfect Skin Regeneration
TL;DR: Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.
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Mutations affecting segment number and polarity in Drosophila
TL;DR: The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
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Angiogenesis in health and disease.
TL;DR: Molecular insights into the formation of new blood vessels are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated.
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Hedgehog signaling in animal development: paradigms and principles.
TL;DR: In their screen for mutations that disrupt the Drosophila larval body plan, these authors identified several that cause the duplication of denticles and an accompanying loss of naked cuticle, characteristic of the posterior half of each segment.