Y-chromosome diversity characterizes the Gulf of Oman
Alicia M. Cadenas,Lev A. Zhivotovsky,Luigi Luca Cavalli-Sforza,Peter A. Underhill,Rene J. Herrera +4 more
TLDR
High-resolution Y-chromosome analysis of males from the United Arab Emirates, Qatar and Yemen revealed high diversity in their Y-haplogroup substructure possibly a result of gene flow along the coastal crescent-shaped corridor of the Gulf of Oman facilitating human dispersals.Abstract:
Arabia has served as a strategic crossroads for human disseminations, providing a natural connection between the distant populations of China and India in the east to the western civilizations along the Mediterranean. To explore this region's critical role in the migratory episodes leaving Africa to Eurasia and back, high-resolution Y-chromosome analysis of males from the United Arab Emirates (164), Qatar (72) and Yemen (62) was performed. The role of the Levant in the Neolithic dispersal of the E3b1-M35 sublineages is supported by the data, and the distribution and STR-based analyses of J1-M267 representatives points to their spread from the north, most likely during the Neolithic. With the exception of Yemen, southern Arabia, South Iran and South Pakistan display high diversity in their Y-haplogroup substructure possibly a result of gene flow along the coastal crescent-shaped corridor of the Gulf of Oman facilitating human dispersals. Elevated rates of consanguinity may have had an impact in Yemen and Qatar, which experience significant heterozygote deficiencies at various hypervariable autosomal STR loci.read more
Citations
More filters
Journal ArticleDOI
Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities
Victoria H. Castleman,Leila Romio,Rahul Chodhari,Robert A. Hirst,Sandra C. P. De Castro,Keith A. Parker,Patricia Ybot-Gonzalez,Richard D. Emes,Stephen W. Wilson,Colin Wallis,Colin A. Johnson,Rene J. Herrera,Andrew Rutman,Mellisa Dixon,Amelia Shoemark,Andrew Bush,Claire Hogg,R. Mark Gardiner,Orit Reish,Nicholas D. E. Greene,Christopher O'Callaghan,Saul Purton,Eddie M.K. Chung,Hannah M. Mitchison +23 more
TL;DR: Investigation of the effect of knockdown or mutations of RSPH9 orthologs in zebrafish and Chlamydomonas indicate that radial spoke head proteins are important in maintaining normal movement in motile, "9+2"-structure cilia and flagella.
Journal ArticleDOI
Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a.
Peter A. Underhill,Natalie M. Myres,Siiri Rootsi,Siiri Rootsi,Mait Metspalu,Mait Metspalu,Lev A. Zhivotovsky,Roy J. King,Alice A. Lin,Cheryl-Emiliane T. Chow,Ornella Semino,Vincenza Battaglia,I. A. Kutuev,I. A. Kutuev,Mari Järve,Gyaneshwer Chaubey,Qasim Ayub,Aisha Mohyuddin,S. Qasim Mehdi,Sanghamitra Sengupta,Evgeny I. Rogaev,Elza Khusnutdinova,Andrey Pshenichnov,Andrey Pshenichnov,Oleg Balanovsky,Oleg Balanovsky,Elena Balanovska,Nina Jeran,Dubravka Havaš Auguštin,Marian Baldovic,Marian Baldovic,Rene J. Herrera,Kumarasamy Thangaraj,Vijay Kumar Singh,Lalji Singh,Partha P. Majumder,Pavao Rudan,Dragan Primorac,Richard Villems,Toomas Kivisild +39 more
TL;DR: The diversity and frequency profiles of M458 suggest its origin during the early Holocene and a subsequent expansion likely related to a number of prehistoric cultural developments in the region, and the virtual absence of M 458 chromosomes outside Europe speaks against substantial patrilineal gene flow from East Europe to Asia, including to India, at least since the mid-Holocene.
Journal ArticleDOI
The phylogenetic and geographic structure of Y-chromosome haplogroup R1a.
Peter A. Underhill,G. David Poznik,Siiri Rootsi,Mari Järve,Alice A. Lin,Jianbin Wang,Ben Passarelli,Jad Kanbar,Natalie M. Myres,Roy J. King,Julie Di Cristofaro,Hovhannes Sahakyan,Doron M. Behar,Alena Kushniarevich,Jelena Šarac,Tena Šarić,Pavao Rudan,Ajai Kumar Pathak,Gyaneshwer Chaubey,Viola Grugni,Ornella Semino,Levon Yepiskoposyan,Ardeshir Bahmanimehr,Shirin Farjadian,Oleg Balanovsky,Elza Khusnutdinova,Rene J. Herrera,Jacques Chiaroni,Carlos Bustamante,Stephen R. Quake,Toomas Kivisild,Richard Villems +31 more
TL;DR: The spatial frequency distributions of R1a sub-haplogroups conclusively indicate two major groups, one found primarily in Europe and the other confined to Central and South Asia.
Journal ArticleDOI
Identifying genetic traces of historical expansions: Phoenician footprints in the Mediterranean
Pierre Zalloua,Pierre Zalloua,Daniel E. Platt,Mirvat El Sibai,Jade Khalife,Nadine J. Makhoul,Marc Haber,Yali Xue,Hassan Izaabel,Elena Bosch,Susan M. Adams,Eduardo Arroyo,Ana María López-Parra,M. Aler,Antònia Picornell,M. Misericordia Ramon,Mark A. Jobling,David Comas,Jaume Bertranpetit,R. Spencer Wells,Chris Tyler-Smith +20 more
TL;DR: The Phoenicians were the dominant traders in the Mediterranean Sea two thousand to three thousand years ago and expanded from their homeland in the Levant to establish colonies and trading posts throughout the Mediterranean, but then they disappeared from history, and male genetic traces in modern populations are identified.
Journal ArticleDOI
Y-chromosomal diversity in Lebanon is structured by recent historical events.
Pierre Zalloua,Yali Xue,Jade Khalife,Nadine J. Makhoul,Labib Debiane,Daniel E. Platt,Ajay K. Royyuru,Rene J. Herrera,David F. Soria Hernanz,Jason Blue-Smith,R. Spencer Wells,David Comas,Jaume Bertranpetit,Chris Tyler-Smith +13 more
TL;DR: The Islamic expansion from the Arabian Peninsula beginning in the seventh century CE introduced lineages typical of this area into those who subsequently became Lebanese Muslims, whereas the Crusader activity in the 11th–13th centuries CE introduced western European lineages into Lebanese Christians.
References
More filters
Journal ArticleDOI
GENEPOP (Version 1.2): Population Genetics Software for Exact Tests and Ecumenicism
Michel Raymond,François Rousset +1 more
Journal ArticleDOI
Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.
TL;DR: In this article, a framework for the study of molecular variation within a single species is presented, where information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-distances among all pairs of haplotypes.
Journal Article
Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.
Journal Article
The history and geography of human genes
Journal ArticleDOI
The History and Geography of Human Genes.
Related Papers (5)
Excavating Y-chromosome haplotype strata in Anatolia
Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area.
Ornella Semino,Chiara Magri,Giorgia Benuzzi,Alice A. Lin,Nadia Al-Zahery,Nadia Al-Zahery,Vincenza Battaglia,L Maccioni,Costas Triantaphyllidis,Peidong Shen,Peter J. Oefner,Lev A. Zhivotovsky,Roy J. King,Antonio Torroni,Luigi Luca Cavalli-Sforza,Peter A. Underhill,A. Silvana Santachiara-Benerecetti +16 more