Zika, Chikungunya, and Other Emerging Vector-Borne Viral Diseases
TLDR
This work discusses Dengue, yellow fever, chikungunya, and Zika viruses, recent arrivals in the Western Hemisphere, and a few other viruses with the potential to emerge through all of these mechanisms.Abstract:
Arthropod-borne viruses (arboviruses) have a long history of emerging to infect humans, but during recent decades, they have been spreading more widely and affecting larger populations. This is due to several factors, including increased air travel and uncontrolled mosquito vector populations. Emergence can involve simple spillover from enzootic (wildlife) cycles, as in the case of West Nile virus accompanying geographic expansion into the Americas; secondary amplification in domesticated animals, as seen with Japanese encephalitis, Venezuelan equine encephalitis, and Rift Valley fever viruses; and urbanization, in which humans become the amplification hosts and peridomestic mosquitoes, mainly Aedes aegypti, mediate human-to-human transmission. Dengue, yellow fever, chikungunya, and Zika viruses have undergone such urban emergence. We focus mainly on the latter two, which are recent arrivals in the Western Hemisphere. We also discuss a few other viruses with the potential to emerge through all of these mechanisms.read more
Citations
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Journal ArticleDOI
Mxra8 is a receptor for multiple arthritogenic alphaviruses
Rong Zhang,Arthur S. Kim,Julie M. Fox,Sharmila Nair,Katherine Basore,William B. Klimstra,Rebecca Rimkunas,Rachel H. Fong,Hueylie Lin,Subhajit Poddar,James E. Crowe,Benjamin J. Doranz,Daved H. Fremont,Michael S. Diamond +13 more
TL;DR: The cell adhesion molecule Mxra8 is identified as a receptor for multiple arthritogenic alphaviruses such as chikungunya virus, and anti-Mxra 8 monoclonal antibodies are shown to reduce rates of chikUNya virus infection in mice and a range of human cells.
Journal ArticleDOI
The mosquito holobiont: fresh insight into mosquito-microbiota interactions.
Morgane Guégan,Karima Zouache,Colin Démichel,Guillaume Minard,Van Tran Van,Patrick Potier,Patrick Mavingui,Claire Valiente Moro +7 more
TL;DR: It is considered that conferring the term holobiont to the mosquito and its microbiota is useful to get a comprehensive understanding of the vector pathosystem functioning so as to be able to develop innovative and efficient novel vector control strategies.
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Rheumatic manifestations of chikungunya: emerging concepts and interventions
TL;DR: The mechanisms by which CHIKV or viral material persists in joint tissues and drives chronic disease are unclear and characterizing the processes involved might open up new avenues for clinical interventions.
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Challenges and Opportunities in Controlling Mosquito-Borne Infections
TL;DR: How new interventions offer the promise of considerable future reductions in disease burden is discussed, however, it is emphasized that intervention programmes need to be underpinned by rigorous trials and quantitative epidemiological analyses.
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Identification of multiple potential viral diseases in a large urban center using wastewater surveillance.
TL;DR: Evaluating the utility of wastewater-based epidemiology for identification and routine monitoring of various viruses in large communities using metagenomics and quantitative polymerase chain reaction assays to identify enteric and non-enteric viruses collected from a large urban area has the potential to improve public health responses to large scale outbreaks and viral pandemics.
References
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Journal ArticleDOI
Zika virus outbreak on Yap Island, Federated States of Micronesia.
Mark R. Duffy,Tai-Ho Chen,W. Thane Hancock,Ann M. Powers,Jacob L. Kool,Robert S. Lanciotti,Moses Pretrick,Maria Marfel,Stacey Holzbauer,Christine Dubray,Laurent Guillaumot,Anne Griggs,Martin Bel,Amy J. Lambert,Janeen Laven,Olga I. Kosoy,Amanda J. Panella,Brad J. Biggerstaff,Marc Fischer,Edward B. Hayes +19 more
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Journal ArticleDOI
Zika Virus Associated with Microcephaly
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Journal ArticleDOI
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
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Journal ArticleDOI
Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.
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TL;DR: Despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities.
Journal ArticleDOI
Present and future arboviral threats.
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