Journal ArticleDOI
Zirconium-Based Porphyrinic Metal–Organic Framework (PCN-222): Enhanced Photoelectrochemical Response and Its Application for Label-Free Phosphoprotein Detection
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TLDR
In this work, in terms of PEC measurements and cyclic voltammetry, the PEC behaviors of PCN-222 in aqueous media were thoroughly investigated for the first time and provide a promising platform for clinic diagnostic and therapeutics.Abstract:
A simple and rapid photoelectrochemical (PEC) sensor was developed for the label-free detection of a phosphoprotein (α-casein) based on a zirconium based porphyrinic metal–organic framework (MOF), PCN-222, which exhibited an enhanced photocurrent response toward dopamine under the O2-saturated aqueous media. In this work, in terms of PEC measurements and cyclic voltammetry, the PEC behaviors of PCN-222 in aqueous media were thoroughly investigated for the first time. Additionally, in the virtue of the steric hindrance effect from the coordination of the phosphate groups and inorganic Zr–O clusters as binding sites in PCN-222, this biosensor showed high sensitivity for detecting α-casein and the limit of detection (LOD) was estimated to be 0.13 μg mL–1. Moreover, the proposed method provides a promising platform for clinic diagnostic and therapeutics.read more
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Journal ArticleDOI
The Applications of Metal−Organic Frameworks in Electrochemical Sensors
TL;DR: In this article, the authors focus on recent progress achieved in metal-organic frameworks (MOF) research with respect to general sensing principles and analytical performances of electrochemical sensors and discuss the evaluation and challenges governing the detection of the assays.
Journal ArticleDOI
Metal–organic frameworks for biosensing and bioimaging applications
TL;DR: In this article, the compositional tenability of metal-organic frameworks (MOFs) imaging platforms should greatly facilitate their further development for clinical translation, as well as their ability to use biocompatible building blocks.
Journal ArticleDOI
Porphyrin‐Based Metal–Organic Frameworks for Biomedical Applications
TL;DR: This Review summarizes important synthesis strategies for porphyrin‐based MOFs including pPHyrin@MOFs, p Morphyrinic MOFs, and composite porphyrsinic MOF and highlights recent achievements and progress in the development of porphirin‐ based MOFs for biomedical applications in tumor therapy and biosensing.
Journal ArticleDOI
Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy.
Xianlong Zhang,Guoliang Li,Guoliang Li,Di Wu,Xiuling Li,Na Hu,Jian Chen,Guang Chen,Yongning Wu +8 more
TL;DR: The most recent contributions in the design construction of the MOFs-based nanozymes are summarized, and their applications in the fields of sensing and cancer therapies are concentrated on.
Journal ArticleDOI
Principles and applications of photoelectrochemical sensing strategies based on biofunctionalized nanostructures.
TL;DR: This review highlights the novel concept on PEC sensing strategies, and categorizes the recent illustrative examples into three signaling principles: reactant determinant, electron transfer and energy transfer, providing the comprehensive design guidelines for researchers to develop more advanced PEC sensors.
References
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Journal ArticleDOI
The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
Journal ArticleDOI
Cell signaling by receptor-tyrosine kinases
TL;DR: Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases.
Journal ArticleDOI
Metal–organic framework materials as catalysts
JeongYong Lee,Omar K. Farha,John M. Roberts,Karl A. Scheidt,SonBinh T. Nguyen,Joseph T. Hupp +5 more
TL;DR: A critical review of the emerging field of MOF-based catalysis is presented and examples of catalysis by homogeneous catalysts incorporated as framework struts or cavity modifiers are presented.
Journal ArticleDOI
Porphyrin-Sensitized Solar Cells with Cobalt (II/III)–Based Redox Electrolyte Exceed 12 Percent Efficiency
Aswani Yella,Hsuan-Wei Lee,Hoi Nok Tsao,Chenyi Yi,Aravind Kumar Chandiran,Md. K. Nazeeruddin,Eric Wei-Guang Diau,Chen-Yu Yeh,Shaik M. Zakeeruddin,Michael Grätzel +9 more
TL;DR: In this article, a Co(II/III)tris(bipyridyl)-based redox electrolyte was used in conjunction with a custom synthesized donor-π-bridge-acceptor zinc porphyrin dye as sensitizer (designated YD2-o-C8).
Journal Article
Porphyrin-sensitized solar cells with cobalt (II/III)-based redox electrolyte exceed 12 percent efficiency (vol 334, pg 629, 2011)
TL;DR: Mesoscopic solar cells that incorporate a Co(II/III)tris(bipyridyl)–based redox electrolyte in conjunction with a custom synthesized donor-π-bridge-acceptor zinc porphyrin dye as sensitizer are reported, enabling attainment of strikingly high photovoltages approaching 1 volt.