L
Laurent F. Thomas
Researcher at Norwegian University of Science and Technology
Publications - 42
Citations - 1398
Laurent F. Thomas is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 10, co-authored 30 publications receiving 589 citations.
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Journal ArticleDOI
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Douglas P Wightman,Iris E. Jansen,Jeanne E. Savage,Alexey A. Shadrin,Shahram Bahrami,Shahram Bahrami,Dominic Holland,Arvid Rongve,Sigrid Børte,Sigrid Børte,Sigrid Børte,Bendik S. Winsvold,Bendik S. Winsvold,Ole Kristian Drange,Amy E Martinsen,Amy E Martinsen,Amy E Martinsen,Anne Heidi Skogholt,Cristen J. Willer,Geir Bråthen,Ingunn Bosnes,Ingunn Bosnes,Jonas B. Nielsen,Jonas B. Nielsen,Jonas B. Nielsen,Lars G. Fritsche,Laurent F. Thomas,Linda M. Pedersen,Maiken Elvestad Gabrielsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Tore Wergeland Meisingset,Wei Zhou,Wei Zhou,Petroula Proitsi,Angela Hodges,Richard Dobson,Latha Velayudhan,Karl Heilbron,Adam Auton,Julia M. Sealock,Lea K. Davis,Nancy L. Pedersen,Chandra A. Reynolds,Ida K. Karlsson,Ida K. Karlsson,Sigurdur H. Magnusson,Hreinn Stefansson,Steinunn Thordardottir,Palmi V. Jonsson,Jon Snaedal,Anna Zettergren,Ingmar Skoog,Ingmar Skoog,Silke Kern,Silke Kern,Margda Waern,Margda Waern,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Eystein Stordal,Eystein Stordal,Kristian Hveem,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,Lavinia Athanasiu,Lavinia Athanasiu,Per Selnes,Ingvild Saltvedt,Sigrid Botne Sando,Ingun Ulstein,Srdjan Djurovic,Srdjan Djurovic,Tormod Fladby,Tormod Fladby,Dag Aarsland,Dag Aarsland,Geir Selbæk,Geir Selbæk,Stephan Ripke,Stephan Ripke,Stephan Ripke,Kari Stefansson,Ole A. Andreassen,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +89 more
TL;DR: This paper identified microglia, immune cells and protein catabolism as relevant genes for late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest.
Journal ArticleDOI
Circular RNAs are depleted of polymorphisms at microRNA binding sites.
Laurent F. Thomas,Pål Sætrom +1 more
TL;DR: Using SNP data from the 1000 Genomes Project, a significant decrease in SNP density was found at miRNA seed sites compared with flanking sequences and random sites, suggesting that many of the predicted miRNA binding sites in circRNAs are functional and under similar selective pressure as miRNAs in mRNAs.
Journal ArticleDOI
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cindy G. Boer,Konstantinos Hatzikotoulas,Lorraine Southam,Lilja Stefansdottir,Yanfei Zhang,Rodrigo Coutinho de Almeida,Tian T Wu,Jie Zheng,April Hartley,Maris Teder-Laving,Anne Heidi Skogholt,Chikashi Terao,Eleni Zengini,George Alexiadis,Andrei Barysenka,Gyda Bjornsdottir,Maiken Elvestad Gabrielsen,Arthur Gilly,Thorvaldur Ingvarsson,Marianne B Johnsen,Helgi Jonsson,Margreet Kloppenburg,Almut Luetge,Sigrun H. Lund,Reedik Mägi,Massimo Mangino,Rob G H H Nelissen,Manu Shivakumar,Julia Steinberg,Hiroshi Takuwa,Laurent F. Thomas,Margo Tuerlings,Hunt All-In Pain,George C. Babis,Jason Pui Yin Cheung,Jae Hee Kang,Peter Kraft,Steven A Lietman,Dino Samartzis,P. Eline Slagboom,Kari Stefansson,Unnur Thorsteinsdottir,Jonathan H Tobias,André G. Uitterlinden,Bendik S. Winsvold,John-Anker Zwart,George Davey Smith,Pak C. Sham,Gudmar Thorleifsson,Tom R. Gaunt,Andrew P. Morris,Ana M. Valdes,Aspasia Tsezou,Kathryn S.E. Cheah,Shiro Ikegawa,Kristian Hveem,Tõnu Esko,J. Mark Wilkinson,Ingrid Meulenbelt,Ming Ta Michael Lee,Joyce B. J. van Meurs,Unnur Styrkarsdottir,Eleftheria Zeggini +62 more
TL;DR: A genome-wide association study meta-analysis across 826,690 individuals and identifies 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before.
Journal ArticleDOI
A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.
Pål Sætrom,Jacob Biesinger,Sierra Min Li,David D. Smith,Laurent F. Thomas,Karim Majzoub,Guillermo E. Rivas,Jessica Alluin,John J. Rossi,Theodore G. Krontiris,Jeffrey N. Weitzel,Mary B. Daly,Al B. Benson,John M. Kirkwood,Peter J. O'Dwyer,Rebecca Sutphen,James A. Stewart,David H. Johnson,Garrett P. Larson +18 more
TL;DR: Results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk, and can help identify and explain the mechanisms behind disease association for alleles that affect miRNA regulation.
Journal ArticleDOI
The importance of p53 pathway genetics in inherited and somatic cancer genomes
Giovanni Stracquadanio,Xuting Wang,Marsha D. Wallace,Anna M. Grawenda,Ping Zhang,Juliet Hewitt,Jorge Zeron-Medina,Francesc Castro-Giner,Ian Tomlinson,Colin R. Goding,Kamil J. Cygan,William G. Fairbrother,Laurent F. Thomas,Pål Sætrom,Federica Gemignani,Stefano Landi,Benjamin Schuster-Böckler,Douglas A. Bell,Gareth L. Bond +18 more
TL;DR: Using newly abundant genomic data, it is demonstrated that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways.