Agata Korecka

TL;DR: It is shown that germ-free pregnant dams, devoid of maternal microbes, have offspring that show increased permeability of the blood-brain barrier, suggesting that crosstalk between the gut microbiota and the brain, initiated during the intrauterine period, is perpetuated throughout life.

TL;DR: The data suggest the existence of a bidirectional AhR-microbiome axis, which influences host metabolic pathways, and exposure to a high-fat diet showed resilience to glucose intolerance.

TL;DR: It is reported that germ-free (GF) mice display altered daily oscillation of clock gene expression with a concomitant change in the expression of clock output regulators, indicating that the microbiome is required for integration of liver clock oscillations that tune output activators and their effectors, thereby regulating metabolic gene expression for optimal liver function.

TL;DR: It is shown that the SCFA butyrate regulates intestinal Angiopoietin-like protein 4 expression in a PPAR-γ-independent manner, and oral administration of SCFA or use ofSCFA-producing bacteria may be additional routes to maintain intestinal ANGPTL4 levels for preventive nutrition or therapeutic purposes.

TL;DR: The latest findings are discussed, including enterotype classification, changes brought on by dysbiosis, gut inflammation, and metabolic mediators in an attempt to underscore the importance of the gut microbiota for human health.