A
Alain Rolland
Researcher at University of Rennes
Publications - 110
Citations - 5825
Alain Rolland is an academic researcher from University of Rennes. The author has contributed to research in topics: Gene delivery & Nucleic acid. The author has an hindex of 38, co-authored 110 publications receiving 5566 citations. Previous affiliations of Alain Rolland include University of California.
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Journal ArticleDOI
Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery
Fiona Maclaughlin,Russell J. Mumper,Jijun Wang,Jenna Tagliaferri,Inder Gill,Mike Hinchcliffe,Alain Rolland +6 more
TL;DR: The combination of strong complex stability and low in vivo expression levels suggest that uptake and/or decomplexation, but not endosomal release, may be the critical rate-limiting steps in the uptake process.
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Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors
Nicholas A. Peppas,Ruth Duncan,Gary E. Wnek,Allan S. Hoffman,Guanghui Gao,Sung Wan Kim,Doo Sung Lee,Michael Hadjiargyrou,Elka Touitou,Denize Ainbinder,Russell J. Mumper,Alain Rolland,Takuro Niidome,Vinod Labhasetwar,Shi Liu,Guangyuan Zhou,Yubin Huang,Zhigang Xie,Xiabin Jing,Noemi Csaba,María J. Alonso,Omar Abdel-Rahman Ali,David J. Mooney,Peter Lönn,Steven F. Dowdy,Si-Shen Feng,Jinming Gao,Eun Seong Lee,Kun Na,You Han Bae,Gaylen M. Zentner,Hye Sung Kim,Hyuk Sang Yoo,Masamichi Nakayama,Teruo Okano,Zi-Xian Liao,Er Yuan Chuang,Chun-Wen Hsiao,Hsing-Wen Sung,Horacio Cabral,Kazunori Kataoka,Praful R. Nair,Dennis E. Discher,Samir Mitragotri +43 more
TL;DR: A compilation of commentaries gives a historical perspective and current status of research covered in some of the most cited research articles in the history of the Journal of Controlled Release.
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Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene.
Paul Blezinger,Jijun Wang,Margaret Gondo,Abraham Quezada,Dorothy Mehrens,Martha French,Arun Singhal,Sean M. Sullivan,Alain Rolland,Rob Ralston,Wang Min +10 more
TL;DR: The sustained production of endostatin by intramuscular gene therapy inhibited both the growth of primary tumors and the development of metastatic lesions, demonstrating the potential utility of intramUScular delivery of an antiangiogenic gene for treatment of disseminated cancers.
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Cationic lipid-based gene delivery systems: pharmaceutical perspectives.
TL;DR: This mini-review provides a critical discussion on cationic lipid-based gene delivery systems and their possible uses as pharmaceuticals.
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Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle
Russell J. Mumper,John G. Duguid,Khursheed Anwer,Melisa K. Barron,Hiroaki Nitta,Alain Rolland +5 more
TL;DR: Interactive polymeric gene delivery systems that increase pDNA bioavailability to muscle cells by both protecting pDNA from nucleases and controlling the dispersion and retention of pDNA in muscle tissue are developed.