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Alyssa Schami
Researcher at Texas Biomedical Research Institute
Publications - 5
Citations - 523
Alyssa Schami is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Gene & Chemokine. The author has an hindex of 3, co-authored 3 publications receiving 181 citations. Previous affiliations of Alyssa Schami include University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Journal ArticleDOI
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.
Dhiraj Kumar Singh,Bindu Singh,Shashank Ganatra,Michal Gazi,Journey Cole,Rajesh Thippeshappa,Kendra J. Alfson,Elizabeth Clemmons,Olga Gonzalez,Ruby Escobedo,Tae-Hyung Lee,Ayan Chatterjee,Yenny Goez-Gazi,Riti Sharan,Maya Gough,Cynthia Alvarez,Alyssa Blakley,Justin Ferdin,Carmen Bartley,Hilary M. Staples,Laura M. Parodi,Jessica Callery,Amanda Mannino,Benjamin Klaffke,Priscilla Escareno,Roy N. Platt,Vida L. Hodara,Julia M. Scordo,Shalini Gautam,Andreu G. Vilanova,Angélica Olmo-Fontánez,Alyssa Schami,Adelekan Oyejide,Dharani Ajithdoss,Richard Copin,Alina Baum,Christos A. Kyratsous,Xavier Alvarez,Mushtaq Ahmed,Bruce A. Rosa,Anna Goodroe,John Dutton,Shannan Hall-Ursone,Patrice A. Frost,Andra K. Voges,Andra K. Voges,Corinna N. Ross,Ken Sayers,Christopher H. Chen,Cory R. A. Hallam,Shabaana A. Khader,Makedonka Mitreva,Tim J. Anderson,Luis Martinez-Sobrido,Jean L. Patterson,Joanne Turner,Jordi B. Torrelles,Edward J. Dick,Kathleen M. Brasky,Larry S. Schlesinger,Luis D. Giavedoni,Ricardo Carrion,Deepak Kaushal +62 more
TL;DR: In this paper, the authors compared acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaques, baboons and old marmosets.
Journal ArticleDOI
Tuberculosis Phenotypic and Genotypic Drug Susceptibility Testing and Immunodiagnostics: A Review
Kizil A. Yusoof,Juan Ignacio García,Alyssa Schami,Andreu Garcia-Vilanova,Holden V. Kelley,Shu-Hua Wang,Adrian Rendon,Blanca I. Restrepo,Marcel Yotebieng,Jordi B. Torrelles +9 more
TL;DR: A call to improve deployable and low-cost TB diagnostic tests to control the DR-TB burden is proposed, especially in light of the increase of the global burden of bacterial antimicrobial resistance, and the potentially long term impact of the coronavirus disease 2019 (COVID-19) disruption on TB programs.
Journal ArticleDOI
The Rv2623-Rv1747 interaction influences phosphatidyl-myo-inositol levels on the cell envelope of Mycobacterium tuberculosis
Alyssa Schami,Wei Ke,Anna Allué-Guardia,Angélica Olmo-Fontánez,John K.C. Chan,Jordi B. Torrelles +5 more
TL;DR: In this paper , the authors investigated the mechanistic regulation of M.tb PIMs levels and its impact on growth and pathogenesis in vitro by assessing multiple strains with Rv2623 or Rv1747 mutated at different amino acids.