A
Angélica Olmo-Fontánez
Researcher at Texas Biomedical Research Institute
Publications - 14
Citations - 596
Angélica Olmo-Fontánez is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 5, co-authored 9 publications receiving 220 citations. Previous affiliations of Angélica Olmo-Fontánez include University of Texas Health Science Center at San Antonio.
Papers
More filters
Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Journal ArticleDOI
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.
Dhiraj Kumar Singh,Bindu Singh,Shashank Ganatra,Michal Gazi,Journey Cole,Rajesh Thippeshappa,Kendra J. Alfson,Elizabeth Clemmons,Olga Gonzalez,Ruby Escobedo,Tae-Hyung Lee,Ayan Chatterjee,Yenny Goez-Gazi,Riti Sharan,Maya Gough,Cynthia Alvarez,Alyssa Blakley,Justin Ferdin,Carmen Bartley,Hilary M. Staples,Laura M. Parodi,Jessica Callery,Amanda Mannino,Benjamin Klaffke,Priscilla Escareno,Roy N. Platt,Vida L. Hodara,Julia M. Scordo,Shalini Gautam,Andreu G. Vilanova,Angélica Olmo-Fontánez,Alyssa Schami,Adelekan Oyejide,Dharani Ajithdoss,Richard Copin,Alina Baum,Christos A. Kyratsous,Xavier Alvarez,Mushtaq Ahmed,Bruce A. Rosa,Anna Goodroe,John Dutton,Shannan Hall-Ursone,Patrice A. Frost,Andra K. Voges,Andra K. Voges,Corinna N. Ross,Ken Sayers,Christopher H. Chen,Cory R. A. Hallam,Shabaana A. Khader,Makedonka Mitreva,Tim J. Anderson,Luis Martinez-Sobrido,Jean L. Patterson,Joanne Turner,Jordi B. Torrelles,Edward J. Dick,Kathleen M. Brasky,Larry S. Schlesinger,Luis D. Giavedoni,Ricardo Carrion,Deepak Kaushal +62 more
TL;DR: In this paper, the authors compared acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaques, baboons and old marmosets.
Journal ArticleDOI
The Lung Mucosa Environment in the Elderly Increases Host Susceptibility to Mycobacterium tuberculosis Infection
Juan I. Moliva,Michael A Duncan,Angélica Olmo-Fontánez,Anwari Akhter,Eusondia Arnett,Julia M. Scordo,Russell Ault,Russell Ault,Smitha J. Sasindran,Abul K. Azad,Maria J. Montoya,Nicole Reinhold-Larsson,Murugesan V. S. Rajaram,Robert E. Merrit,William P. Lafuse,Liwen Zhang,Shu-Hua Wang,Gillian Beamer,Yufeng Wang,Kevin Proud,Diego J. Maselli,Jay I. Peters,Susan T. Weintraub,Joanne Turner,Joanne Turner,Larry S. Schlesinger,Larry S. Schlesinger,Jordi B. Torrelles,Jordi B. Torrelles +28 more
TL;DR: The studies demonstrate how the pulmonary environment changes as the authors age and suggest that M.tb may benefit from declining host defenses in the lung mucosa of the elderly.
Journal ArticleDOI
The human lung mucosa drives differential Mycobacterium tuberculosis infection outcome in the alveolar epithelium
Julia M. Scordo,Julia M. Scordo,Angélica Olmo-Fontánez,Holden V. Kelley,Holden V. Kelley,Sabeen Sidiki,Jesus Arcos,Anwari Akhter,Mark D. Wewers,Jordi B. Torrelles,Jordi B. Torrelles +10 more
TL;DR: The results indicate that dysfunctionality of innate proteins in the H-ALF phenotype promotes M.tb replication within ATs, while limiting inflammation and phagocyte activation, thus potentiating ATs as a reservoir for M.Tb replication and survival.