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Anna Allué-Guardia
Researcher at Texas Biomedical Research Institute
Publications - 9
Citations - 555
Anna Allué-Guardia is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Viral pathogenesis & Virus. The author has an hindex of 4, co-authored 9 publications receiving 137 citations.
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Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Journal ArticleDOI
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice.
Jesus Silvas,Desarey Morales Vasquez,Jun-Gyu Park,Kevin Chiem,Anna Allué-Guardia,Andreu Garcia-Vilanova,Roy N. Platt,Lisa Miorin,Thomas Kehrer,Anastasija Cupic,Ana S. Gonzalez-Reiche,Harm van Bakel,Adolfo García-Sastre,Tim J. Anderson,Jordi B. Torrelles,Chengjin Ye,Luis Martinez-Sobrido +16 more
TL;DR: In this article, a reverse-genetics system was used to generate recombinant SARS-CoV-2 (rSARSCoV2) constructs, and the resulting recombinant viruses were characterized in vitro and in vivo.
Journal ArticleDOI
Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment
TL;DR: In this article, the authors discuss Mtb phenotypic and genotypic changes driving resistance, including changes in cell envelope components, as well as recently described intrinsic and extrinsic factors promoting resistance emergence and transmission.
Journal ArticleDOI
Mycobacteriophages as Potential Therapeutic Agents against Drug-Resistant Tuberculosis.
TL;DR: In this article, a review of mycobacteriophages and their mechanisms of killing M. tuberculosis strains is presented, as well as their advantages and limitations as therapeutic and prophylactic agents against drug-resistant M tuberculosis strains.