Colwyn A. Headley

TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.

TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.

TL;DR: Comparing pig mandibular and tibia BMSCs for their in vitro proliferation, osteogenic differentiation properties and gene expression indicates that despite strong similarities in gene expression between mandibULAR and tibial B MSCs,Mandibular BMSC express some genes differently than tibials and have a phenotypic profile that may make them advantageous for craniofacial bone regeneration.

TL;DR: It is demonstrated that the nitrones reverse the deleterious effects of hyperglycemia in BAEC, and in vivo testing of these nitrone compounds in models of cardiometabolic disease is warranted.

TL;DR: In this paper, a set of seven hydroxycoumarin derivatives (1, 7) were tested to evaluate their antioxidant properties against peroxyl and hydroxyl radicals using two different assays, namely oxygen radical antioxidant capacity (ORAC) and non-catalytic Fenton system by ESR measurements.