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Xavier Alvarez
Researcher at Texas Biomedical Research Institute
Publications - 5
Citations - 561
Xavier Alvarez is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Chemokine & Viral pathogenesis. The author has an hindex of 4, co-authored 5 publications receiving 210 citations.
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Journal ArticleDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
Journal ArticleDOI
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.
Dhiraj Kumar Singh,Bindu Singh,Shashank Ganatra,Michal Gazi,Journey Cole,Rajesh Thippeshappa,Kendra J. Alfson,Elizabeth Clemmons,Olga Gonzalez,Ruby Escobedo,Tae-Hyung Lee,Ayan Chatterjee,Yenny Goez-Gazi,Riti Sharan,Maya Gough,Cynthia Alvarez,Alyssa Blakley,Justin Ferdin,Carmen Bartley,Hilary M. Staples,Laura M. Parodi,Jessica Callery,Amanda Mannino,Benjamin Klaffke,Priscilla Escareno,Roy N. Platt,Vida L. Hodara,Julia M. Scordo,Shalini Gautam,Andreu G. Vilanova,Angélica Olmo-Fontánez,Alyssa Schami,Adelekan Oyejide,Dharani Ajithdoss,Richard Copin,Alina Baum,Christos A. Kyratsous,Xavier Alvarez,Mushtaq Ahmed,Bruce A. Rosa,Anna Goodroe,John Dutton,Shannan Hall-Ursone,Patrice A. Frost,Andra K. Voges,Andra K. Voges,Corinna N. Ross,Ken Sayers,Christopher H. Chen,Cory R. A. Hallam,Shabaana A. Khader,Makedonka Mitreva,Tim J. Anderson,Luis Martinez-Sobrido,Jean L. Patterson,Joanne Turner,Jordi B. Torrelles,Edward J. Dick,Kathleen M. Brasky,Larry S. Schlesinger,Luis D. Giavedoni,Ricardo Carrion,Deepak Kaushal +62 more
TL;DR: In this paper, the authors compared acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaques, baboons and old marmosets.
Posted ContentDOI
SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
Dhiraj Kumar Singh,Shashank Ganatra,Bindu Singh,Journey Cole,Kendra J. Alfson,Elizabeth Clemmons,Michal Gazi,Olga Gonzalez,Ruby Escabedo,Tae-Hyung Lee,Ayan Chatterjee,Yenny Goez-Gazi,Riti Sharan,Rajesh Thippeshappa,Maya Gough,Cynthia Alvarez,Alyssa Blakely,Justin Ferdin,Carmen Bartley,Hilary M. Staples,Laura M. Parodi,Jessica Callery,Amanda Mannino,Benjamin Klaffke,Priscilla Escareno,Roy N. Platt,Vida L. Hodara,Julia M. Scordo,Adelekan Oyejide,Dharani Ajithdoss,Richard Copin,Alina Baum,Christos A. Kyratsous,Xavier Alvarez,Bruce A. Rosa,Mushtaq Ahmed,Anna Goodroe,John Dutton,Shannan Hall-Ursone,Patrice A. Frost,Andra K. Voges,Corinna N. Ross,Ken Sayers,Christopher H. Chen,Cory R. A. Hallam,Shabaana A. Khader,Makedonka Mitreva,Tim J. Anderson,Luis Martinez-Sobrido,Jean L. Patterson,Joanne Turner,Jordi B. Torrelles,Edward J. Dick,Kathleen M. Brasky,Larry S. Schlesinger,Luis D. Giavedoni,Deepak Kaushal,Ricardo Carrion +57 more
TL;DR: These results showcase in critical detail, the robust early cellular immune responses to SARS-CoV-2 infection, which are not sterilizing and likely impact development of antibody responses.
Journal ArticleDOI
Long Term Delta-9-tetrahydrocannabinol Administration Inhibits Proinflammatory Responses in Minor Salivary Glands of Chronically Simian Immunodeficieny Virus Infected Rhesus Macaques.
TL;DR: Preliminary translational findings suggest that phytocannabinoids may safely and effectively reduce oral inflammatory responses in HIV/SIV and other (autoimmune) diseases.