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Amir Mitchell
Researcher at University of Massachusetts Medical School
Publications - 15
Citations - 1371
Amir Mitchell is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Microbiome & Drug resistance. The author has an hindex of 10, co-authored 14 publications receiving 1081 citations. Previous affiliations of Amir Mitchell include Weizmann Institute of Science & Tel Aviv University.
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Journal ArticleDOI
Adaptive Prediction of Environmental Changes by Microorganisms
Amir Mitchell,Gal Hagit Romano,Bella Groisman,Avihu H. Yona,Erez Dekel,Martin Kupiec,Orna Dahan,Yitzhak Pilpel,Yitzhak Pilpel +8 more
TL;DR: It is shown that anticipation is an adaptive trait, because pre-exposure to the stimulus that typically appears early in the ecology improves the organism’s fitness when encountered with a second stimulus, and indicates that environmental anticipation may be ubiquitous in biology.
Journal ArticleDOI
Chromosomal duplication is a transient evolutionary solution to stress
Avihu H. Yona,Yair S. Manor,Rebecca H. Herbst,Gal Hagit Romano,Amir Mitchell,Martin Kupiec,Yitzhak Pilpel,Orna Dahan +7 more
TL;DR: It is shown that chromosomal duplications are first acquired as a crude solution to stress, yet only as transient solutions that are eliminated and replaced by more efficient solutions obtained at the individual gene level, which indicates that aneuploidy is a useful yet short-lived intermediate that facilitates further adaptation.
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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View
Joao B. Xavier,Vincent B. Young,Joseph D. Skufca,Fiona Ginty,Traci L. Testerman,Alexander T. Pearson,Paul Macklin,Amir Mitchell,Ilya Shmulevich,Lei Xie,J. Gregory Caporaso,Keith A. Crandall,Nicole L. Simone,Filipa Godoy-Vitorino,Timothy J. Griffin,Katrine Whiteson,Heather H. Gustafson,Daniel J. Slade,Thomas M. Schmidt,Marina Walther-Antonio,Tal Korem,Bobbie-Jo M. Webb-Robertson,Mark P. Styczynski,W. Evan Johnson,Christian Jobin,Jason M. Ridlon,Andrew Y. Koh,Michael Yu,Libusha Kelly,Jennifer A. Wargo +29 more
TL;DR: Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach.
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Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
Lukasz J. Bugaj,Amit J. Sabnis,Amir Mitchell,Joan E. Garbarino,Jared E. Toettcher,Trever G. Bivona,Wendell A. Lim +6 more
TL;DR: Cancer mutations and targeted drugs can corrupt dynamic transmission properties in signaling pathways, shifting cellular response thresholds and changing cell decisions in a potentially pathological manner.
Journal ArticleDOI
Oscillatory stress stimulation uncovers an Achilles’ heel of the yeast MAPK signaling network
TL;DR: The findings demonstrate the value of non-natural dynamic perturbations in exposing hidden sensitivities of cellular regulatory networks, and identify similar fragility in other regulatory pathways.