A
Amy L. Williams
Researcher at Cornell University
Publications - 43
Citations - 6716
Amy L. Williams is an academic researcher from Cornell University. The author has contributed to research in topics: Identity by descent & Genome-wide association study. The author has an hindex of 20, co-authored 40 publications receiving 6131 citations. Previous affiliations of Amy L. Williams include University of Utah & Howard Hughes Medical Institute.
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Journal ArticleDOI
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Denise Harold,Richard Abraham,Paul Hollingworth,Rebecca Sims,Amy Gerrish,Marian L. Hamshere,Jaspreet Singh Pahwa,Valentina Moskvina,Kimberley Dowzell,Amy L. Williams,Nicola L. Jones,Charlene Thomas,Alexandra Stretton,Angharad R. Morgan,Simon Lovestone,John Powell,Petroula Proitsi,Michelle K. Lupton,Carol Brayne,David C. Rubinsztein,Michael Gill,Brian A. Lawlor,Aoibhinn Lynch,Kevin Morgan,Kristelle Brown,Peter Passmore,David Craig,Bernadette McGuinness,Stephen Todd,Clive Holmes,David M. A. Mann,A. David Smith,Seth Love,Patrick G. Kehoe,John Hardy,Simon Mead,Nick C. Fox,Martin N. Rossor,John Collinge,Wolfgang Maier,Frank Jessen,Britta Schürmann,Hendrik van den Bussche,Isabella Heuser,Johannes Kornhuber,Jens Wiltfang,Martin Dichgans,Lutz Frölich,Harald Hampel,Harald Hampel,Michael Hüll,Dan Rujescu,Alison Goate,John S. K. Kauwe,Carlos Cruchaga,Petra Nowotny,John C. Morris,Kevin Mayo,Kristel Sleegers,Karolien Bettens,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Gill Livingston,Nicholas Bass,Hugh Gurling,Andrew McQuillin,Rhian Gwilliam,Panagiotis Deloukas,Ammar Al-Chalabi,Christopher Shaw,Magda Tsolaki,Andrew B. Singleton,Rita Guerreiro,Thomas W. Mühleisen,Markus M. Nöthen,Susanne Moebus,Karl-Heinz Jöckel,Norman Klopp,H-Erich Wichmann,Minerva M. Carrasquillo,V. Shane Pankratz,Steven G. Younkin,Peter Holmans,Michael Conlon O'Donovan,Michael John Owen,Julie Williams +86 more
TL;DR: A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer's Disease in the combined dataset.
Journal ArticleDOI
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease
Denise Harold,Richard Abraham,Paul Hollingworth,Rebecca Sims,Amy Gerrish,Marian L. Hamshere,Jaspreet Singh Pahwa,Valentina Moskvina,Kimberley Dowzell,Amy L. Williams,Nicola Jones,Charlene Thomas,Alexandra Stretton,Angharad R. Morgan,Simon Lovestone,John Powell,Petroula Proitsi,Michelle K. Lupton,Carol Brayne,David C. Rubinsztein,Michael Gill,Brian A. Lawlor,Aoibhinn Lynch,Kevin Morgan,Kristelle Brown,Peter Passmore,David Craig,Bernadette McGuinness,Stephen Todd,Clive Holmes,David G. Mann,A. David Smith,Seth Love,Patrick G. Kehoe,John Hardy,Simon Mead,Nick C. Fox,Martin N. Rossor,John Collinge,Wolfgang Maier,Frank Jessen,Britta Schürmann,Reinhard Heun,Hendrik van den Bussche,Isabella Heuser,Johannes Kornhuber,Jens Wiltfang,Martin Dichgans,Lutz Frölich,Harald Hampel,Michael Hüll,Dan Rujescu,Alison Goate,John S. K. Kauwe,Carlos Cruchaga,Petra Nowotny,John C. Morris,Kevin Mayo,Kristel Sleegers,Karolien Bettens,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Gill Livingston,Nicholas Bass,Hugh Gurling,Andrew McQuillin,Rhian Gwilliam,Panagiotis Deloukas,Ammar Al-Chalabi,Christopher Shaw,Magda Tsolaki,Andrew B. Singleton,Rita Guerreiro,Thomas W Mühleisen,Markus M Nöthen,Susanne Moebus,Karl-Heinz Jöckel,Norman Klopp,H-Erich Wichmann,Minerva M. Carrasquillo,V. Shane Pankratz,Steven G. Younkin,Peter Holmans,Michael OtextquotesingleDonovan,Michael John Owen,Julie Williams +86 more
TL;DR: A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer’s disease in the combined dataset.
Journal Article
National Institutes of Health Consensus Development Conference panel statement: Management of hepatitis C
Don W. Powell,B. Z. Abramson,J. A. Balint,Steven H. Belle,J. R. Bloomer,A. K. Diehl,J. T. Frakes,G. Garcia-Tsao,E. W. Hook,J. M. Lusher,M. A. Popovsky,L. Rabeneck,Amy L. Williams,Tommie Sue Tralka,H. J. Alter,Miriam J. Alter,Elsa A. Bray,L. Curtis,Jay E. Everhart,Stephen M. Feinstone,John H. Ferguson,J. S. Gress,William H. Hall,Jay H. Hoofnagle,L. D. Johnson,Thomas F. Kresina,Karen L. Lindsay,Anna S.F. Lok,P. R. McCurdy,Robert P. Perrillo,Robert H. Purcell,Eugene R. Schiff,W. D. Schwieterman,Leonard B. Seeff,C. R. Sherman,M. H. Stolar,A. Trachtenberg +36 more
TL;DR: A responsible assessment of current available methods to diagnose, treat, and manage hepatitis C is provided to provide health care providers, patients, and the general public with a responsible assessment.
Journal ArticleDOI
Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.
TL;DR: The authors showed that cognitive function can be impaired for at least two months after the resolution of a systemic infection and that cognitive impairment is preceded by raised serum levels of interleukin 1β.
Journal ArticleDOI
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
Karol Estrada,Karol Estrada,Ingvild Aukrust,Ingvild Aukrust,Lise Bjørkhaug,Noël P. Burtt,Josep M. Mercader,Humberto García-Ortiz,Alicia Huerta-Chagoya,Hortensia Moreno-Macías,Geoffrey A. Walford,Jason Flannick,Amy L. Williams,Amy L. Williams,María José Gómez-Vázquez,Juan Carlos Fernández-López,Angélica Martínez-Hernández,Silvia Jiménez-Morales,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Córdova,Xavier Soberón,María Elena González-Villalpando,E. Henderson,Lynne R. Wilkens,Loic Le Marchand,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Rosario Rodríguez-Guillén,Laura Riba,Laeya A. Najmi,Suzanne B.R. Jacobs,Timothy Fennell,Stacey Gabriel,Pierre Fontanillas,Craig L. Hanis,Donna M. Lehman,Christopher P. Jenkinson,Hanna E. Abboud,Graeme I. Bell,Maria L. Cortes,Michael Boehnke,Clicerio Gonzalez-Villalpando,Lorena Orozco,Christopher A. Haiman,Teresa Tusie-Luna,Carlos A. Aguilar-Salinas,David Altshuler,Pål R. Njølstad,Jose C. Florez,Jose C. Florez,Daniel G. MacArthur,Daniel G. MacArthur +55 more
TL;DR: A single low-frequency variant in the MODY3-causing gene HNF1A that is associated with type 2 diabetes in Latino populations and may affect protein function is identified and may have implications for screening and therapeutic modification in this population.