R
Rosario Rodríguez-Guillén
Researcher at National Autonomous University of Mexico
Publications - 17
Citations - 1109
Rosario Rodríguez-Guillén is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 10, co-authored 17 publications receiving 929 citations. Previous affiliations of Rosario Rodríguez-Guillén include Universidad Autónoma Metropolitana & Consejo Nacional de Ciencia y Tecnología.
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Journal ArticleDOI
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
A. L. Williams Amy,A. L. Williams Amy,S. B R Jacobs Suzanne,Hortensia Moreno-Macías,Alicia Huerta-Chagoya,Claire Churchhouse,Carla Marquez-Luna,María José Gómez-Vázquez,N. P. Burtt Noël,Carlos A. Aguilar-Salinas,Clicerio Gonzalez-Villalpando,Jose C. Florez,Jose C. Florez,Lorena Orozco,Teresa Tusié-Luna,David Altshuler,David Altshuler,David Altshuler,Stephan Ripke,Stephan Ripke,Alisa K. Manning,Humberto García-Ortiz,Benjamin M. Neale,Benjamin M. Neale,David Reich,David Reich,Daniel O. Stram,Juan Carlos Fernández-López,Sandra Romero-Hidalgo,Nick Patterson,Christopher A. Haiman,Irma Aguilar-Delfín,Angélica Martínez-Hernández,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Eunice Rodríguez-Arellano,Xavier Soberón,J. C. Florez Jose,J. C. Florez Jose,M. A. González-Villalpando María Elena,Brian E. Henderson,Kristine R. Monroe,Lynne R. Wilkens,Laurence N. Kolonel,Loic Le Marchand,Laura Riba,M. A. Ordóñez-Sánchez María Luisa,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Maribel Rodríguez-Torres,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Robert C. Onofrio,Wendy Brodeur,Diane Gage,Jacquelyn Murphy,Jennifer Franklin,Scott Mahan,Kristin G. Ardlie,Andrew Crenshaw,Wendy Winckler,Kay Prüfer,Michael V. Shunkov,Susanna Sawyer,Udo Stenzel,Janet Kelso,Monkol Lek,Monkol Lek,Sriram Sankararaman,Sriram Sankararaman,Daniel G. MacArthur,Daniel G. MacArthur,A.P. Derevianko,Svante Pääbo,Suzanne B.R. Jacobs,Shuba Gopal,James A. Grammatikos,Ian Smith,Kevin Bullock,Amy Deik,Amanda Souza,Kerry A. Pierce,Clary B. Clish,Timothy Fennell,Yossi Farjoun,Stacey Gabriel,Myron D. Gross,Mark A. Pereira,Mark Seielstad,Woon-Puay Koh,E. Shyong Tai,Jason Flannick,Jason Flannick,Pierre Fontanillas,Andrew D. Morris,Tanya M. Teslovich,Gil Atzmon,John Blangero,Donald W. Bowden,John C. Chambers,John C. Chambers,Yoon Shin Cho,Ravindranath Duggirala,Benjamin Glaser,Benjamin Glaser,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Jong-Young Lee,Yik Ying Teo,Yik Ying Teo,James G. Wilson,Sobha Puppala,Vidya S. Farook,Farook Thameem,Hanna E. Abboud,Ralph A. DeFronzo,Christopher P. Jenkinson,Donna M. Lehman,Joanne E. Curran,Maria L. Cortes,C. González-Villalpando Clicerio,L. Orozco Lorena +128 more
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Journal ArticleDOI
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
Karol Estrada,Karol Estrada,Ingvild Aukrust,Ingvild Aukrust,Lise Bjørkhaug,Noël P. Burtt,Josep M. Mercader,Humberto García-Ortiz,Alicia Huerta-Chagoya,Hortensia Moreno-Macías,Geoffrey A. Walford,Jason Flannick,Amy L. Williams,Amy L. Williams,María José Gómez-Vázquez,Juan Carlos Fernández-López,Angélica Martínez-Hernández,Silvia Jiménez-Morales,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Córdova,Xavier Soberón,María Elena González-Villalpando,E. Henderson,Lynne R. Wilkens,Loic Le Marchand,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Rosario Rodríguez-Guillén,Laura Riba,Laeya A. Najmi,Suzanne B.R. Jacobs,Timothy Fennell,Stacey Gabriel,Pierre Fontanillas,Craig L. Hanis,Donna M. Lehman,Christopher P. Jenkinson,Hanna E. Abboud,Graeme I. Bell,Maria L. Cortes,Michael Boehnke,Clicerio Gonzalez-Villalpando,Lorena Orozco,Christopher A. Haiman,Teresa Tusie-Luna,Carlos A. Aguilar-Salinas,David Altshuler,Pål R. Njølstad,Jose C. Florez,Jose C. Florez,Daniel G. MacArthur,Daniel G. MacArthur +55 more
TL;DR: A single low-frequency variant in the MODY3-causing gene HNF1A that is associated with type 2 diabetes in Latino populations and may affect protein function is identified and may have implications for screening and therapeutic modification in this population.
Journal ArticleDOI
Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population
Marco Alberto Gamboa-Meléndez,Alicia Huerta-Chagoya,Hortensia Moreno-Macías,Hortensia Moreno-Macías,Paola Vázquez-Cárdenas,María Luisa Ordóñez-Sánchez,Rosario Rodríguez-Guillén,Laura Riba,Maribel Rodríguez-Torres,María Teresa Guerra-García,Luz E. Guillén-Pineda,Shweta Choudhry,Laura del Bosque-Plata,Samuel Canizales-Quinteros,Gustavo Pérez-Ortiz,Fernando Escobedo-Aguirre,Adalberto Parra,Israel Lerman-Garber,Carlos A. Aguilar-Salinas,María Teresa Tusié-Luna +19 more
TL;DR: association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1), but Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects
Journal ArticleDOI
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
Arthur Ko,Rita M. Cantor,Daphna Weissglas-Volkov,Elina Nikkola,Prasad M. V. Linga Reddy,Janet S. Sinsheimer,Bogdan Pasaniuc,Robert Brown,Marcus Alvarez,Alejandra Rodriguez,Rosario Rodríguez-Guillén,Ivette Cruz Bautista,Olimpia Arellano-Campos,Linda L. Muñoz-Hernández,Veikko Salomaa,Jaakko Kaprio,Jaakko Kaprio,Antti Jula,Matti Jauhiainen,Markku Heliövaara,Olli T. Raitakari,Olli T. Raitakari,Terho Lehtimäki,Johan G. Eriksson,Johan G. Eriksson,Markus Perola,Markus Perola,Markus Perola,Kirk E. Lohmueller,Niina Matikainen,Marja-Riitta Taskinen,Maribel Rodríguez-Torres,Laura Riba,Teresa Tusie-Luna,Carlos A. Aguilar-Salinas,Päivi Pajukanta +35 more
TL;DR: In this paper, a cross-population allele screen (CPAS) was used to identify Amerindian risk genes in Mexicans. But the authors did not identify any Amerindians with dyslipidemia or obesity.
Journal ArticleDOI
Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women.
Alicia Huerta-Chagoya,Paola Vázquez-Cárdenas,Hortensia Moreno-Macías,Leonardo Tapia-Maruri,Rosario Rodríguez-Guillén,Erika López-Vite,Guadalupe Garcia-Escalante,Fernando Escobedo-Aguirre,Adalberto Parra-Covarrubias,Roberto Cordero-Brieño,Lizette Manzo-Carrillo,Rogelio Zacarías-Castillo,Carlos Vargas-García,Carlos A. Aguilar-Salinas,Teresa Tusié-Luna +14 more
TL;DR: The fact that two of the main T2D associated loci also contribute to the risk of developing GDM in Mexicans, confirm that both diseases share a common genetic background.