Salimata Bagayoko

TL;DR: In this article , the authors identify the NLRP1 inflammasome as a sensor of SARS-CoV-2 infection in lung epithelia and demonstrate that 3CL proteases also inactivate the pyroptosis executioner Gasdermin D (GSDMD).

TL;DR: This work shows that the IFN‐inducible protein Irgm2 and the ATG8 family member Gate‐16 cooperatively counteract Gram‐negative bacteria‐induced non‐canonical inflammasome activation, both in cultured macrophages and in vivo.

TL;DR: It is demonstrated that neutrophils are not universally resistant for Caspase-1-dependent pyroptosis, and contributes to IL-1β production and susceptibility to pyroPTosis-inducing P. aeruginosa strains in vivo.

TL;DR: In this paper, the authors mainly focus on the emerging involvement of lipid peroxidation-driven ferroptosis in infectious diseases and the immune consequences, and discuss the putative ability of microbial virulence factors to exploit or to dampen FerroPTosis regulatory pathways to their own benefit.

TL;DR: In this paper, the authors investigated the molecular and cellular mechanisms of ExoU-mediated necrosis and showed that cellular peroxidised phospholipids enhance ExoUs activity, which drives necrosis of immune and non-immune cells.