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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
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Journal ArticleDOI
Policy reforms to update chemical safety testing
Andre E. Nel,Timothy F. Malloy +1 more
TL;DR: This paradigm, relying largely on nonanimal, alternative testing strategies (ATS), uses mechanism-based in vitro assays and in silico predictive tools for testing chemicals at considerably less cost and is provided a cautious but hopeful assessment of this intersection of law and science.
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A Bayesian regression tree approach to identify the effect of nanoparticles' properties on toxicity profiles
Cecile Low-Kam,Donatello Telesca,Zhaoxia Ji,Haiyuan Zhang,Tian Xia,Jeffrey I. Zink,Andre E. Nel +6 more
TL;DR: In this article, a Bayesian multiple regression tree model is proposed to characterize relationships between physico-chemical properties of nanoparticles and their in-vitro toxicity over multiple doses and times of exposure.
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An update on the immunopathogenesis of asthma as an inflammatory disease enhanced by environmental pollutants.
Adrian M. Casillas,Andre E. Nel +1 more
TL;DR: The pathogenesis of asthma now centers on the role of bronchial mucosal inflammation of mixed cellularity in addition to the characteristic airways hyperresponsiveness and reversible obstruction, and a mounting body of evidence exists to explain the recent increases in allergic disease prevalence.
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Phosphorylation of human serum amyloid A protein by protein kinase C.
TL;DR: Potential phosphorylation of HDL3 apolipoproteins by protein kinase C was selective for the more basic isoforms of apo-SAA, but was not in itself responsible for the establishment of the apo -SAA isoforms.
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Cholera toxin partially inhibits the T-cell response to phytohaemagglutinin through the ADP-ribosylation of a 45 kDa membrane protein.
TL;DR: It would seem as if reduction in inositol phospholipid turnover is related to the elevation of cyclic AMP rather than a CT effect on a putative transducer which acts directly onospholipase C, although this study does not exclude the existence of non-CT-sensitive transducers in this capacity.