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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
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Journal ArticleDOI
Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter
TL;DR: It is demonstrated that it is possible to use the stratified oxidative stress model developed for DEP to interpret the biological effects of coarse and fine PM, and has important implications for the selection of relevant biological endpoints for in vivo studies.
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Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential
Xiang Wang,Zhaoxia Ji,Chong Hyun Chang,Haiyuan Zhang,Meiying Wang,Yu-Pei Liao,Sijie Lin,Huan Meng,Ruibin Li,Bingbing Sun,Laura S. Van Winkle,Kent E. Pinkerton,Jeffrey I. Zink,Tian Xia,Andre E. Nel +14 more
TL;DR: It is demonstrated that size and surface coating affect the cellular toxicity of Ag NPs as well as their acute versus sub-chronic lung injury potential.
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Best Practices in Cancer Nanotechnology: Perspective from NCI Nanotechnology Alliance
William C. Zamboni,Vladimir P. Torchilin,Anil K. Patri,Jeff Hrkach,Stephen Stern,Robert J. Lee,Andre E. Nel,Nicholas J. Panaro,Piotr Grodzinski +8 more
TL;DR: The challenges in optimizing design of nanoparticles tailored to specific tumor indications still remain; however, it is clear that nanoscale devices carry a significant promise toward new ways of diagnosing and treating cancer.
Journal Article
The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.
Mary Faris,Niels Kokot,Kevin M. Latinis,Shailaja Kasibhatla,Douglas R. Green,Gary A. Koretzky,Andre E. Nel +6 more
TL;DR: The data show that while the JNK pathway contributes to stress-induced apoptosis in T lymphocytes by regulating FasL expression, not all stress stimuli use the same cell death pathway.
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The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes.
TL;DR: It is shown that CD3/CD28-induced activation of IKKβ and expression of Bcl-xL promote the survival of primary human CD4+ T lymphocytes, a prominent anti-apoptotic member among a number of early CD28-inducible genes.