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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
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Journal ArticleDOI
Tracheobronchial Particle Dose Considerations for In Vitro Toxicology Studies
TL;DR: A method for estimating particle doses that may be used to reconcile particle deposition doses used in in vitro toxicology studies with in vivo exposure levels is presented, and three particle exposure scenarios are proposed.
Journal Article
Macrophage Activation by Polycyclic Aromatic Hydrocarbons: Evidence for the Involvement of Stress-Activated Protein Kinases, Activator Protein-1, and Antioxidant Response Elements
TL;DR: It is demonstrated that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines.
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Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract
Sijie Lin,Xiang Wang,Zhaoxia Ji,Chong Hyun Chang,Yuan Dong,Huan Meng,Yu-Pei Liao,Meiying Wang,Tze-Bin Song,Sirus A. Kohan,Tian Xia,Jeffrey I. Zink,Shuo Lin,Andre E. Nel +13 more
TL;DR: Comparative studies in the mouse lung and gastrointestinal tract (GIT) of zebrafish larvae demonstrate that, similar to cellular studies, LAR CeO2 nanorods exhibit more toxicity in the lung and GIT, which could be relevant to inhalation and environmental hazard potential.
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Interlaboratory comparison of size and surface charge measurements on nanoparticles prior to biological impact assessment
Gert Roebben,Sonia Ramirez-Garcia,Vincent A. Hackley,Matthias Roesslein,Frederick Klaessig,Vikram Kestens,Iseult Lynch,C. M. Garner,Alan F. Rawle,Alison Elder,Vicki L. Colvin,Wolfgang G. Kreyling,Harald F. Krug,Zuzanna A. Lewicka,Scott E. McNeil,Andre E. Nel,Anil K. Patri,Peter Wick,Mark R. Wiesner,Tian Xia,Günter Oberdörster,Kenneth A. Dawson +21 more
TL;DR: In this paper, the results of the first IANH round robin studies into methods to assess the size and surface charge of suspended nanoparticles were presented, and robust statistical analysis was used to evaluate within and between-laboratory variability.
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Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells
TL;DR: SFN and NAC upregulate T(H)1 immunity in aging through a restoration of redox equilibrium through the inhibition of Nrf2 deficiency and boosting of GSH levels by the thiol precursor N-acetyl cysteine.