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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
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Journal ArticleDOI
Nitrotyrosine‐modified proteins and oxidative stress induced by diesel exhaust particles
TL;DR: It is shown that the induction of oxidative stress is accompanied by 53 newly expressed proteins which are suppressed by a thiol antioxidant, N‐acetylcysteine, and these include antioxidant enzymes, pro‐inflammatory components, and products of intermediary metabolism.
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Activation of the Human RANTES Gene Promoter in a Macrophage Cell Line by Lipopolysaccharide Is Dependent on Stress-Activated Protein Kinases and the IκB Kinase Cascade: Implications for Exacerbation of Allergic Inflammation by Environmental Pollutants
TL;DR: It is demonstrated that transcriptional activation of the human RANTES promoter by LPS is dependent on specific AP-1 andNF-kappaB response elements, which are regulated by c-Jun N-terminal kinase (JNK) and NF- kappaB kinase cascades, respectively.
Journal Article
CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase.
Andre E. Nel,Shimon Pollack,Gary E. Landreth,Jeffrey A. Ledbetter,Lance E. Hultin,Katherine Williams,Rina Katz,Brian J. Akerley +7 more
TL;DR: It is suggested that coaggregation of CD4 and CD3 with cross-linking antibodies and avidin may create the conditions whereby MAP-2K may be activated by dual phosphorylation, and that independent aggregation of these receptors may lead to physical separation and breakdown of this interactive mechanism.
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Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles that are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression.
Haiyuan Zhang,Xiang Wang,Meiying Wang,Linjiang Li,Chong Hyun Chang,Zhaoxia Ji,Tian Xia,Andre E. Nel +7 more
TL;DR: Differences in anti-oxidant defense and metallothionein expression among different cell types are observed, which can partially explain differential Ag NP sensitivity, and are important to consider in understanding the potential heterogeneous effects of nano Ag on mammalian biological systems.
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Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization.
Nicolas W.J. Schröder,Timothy R. Crother,Yoshikazu Naiki,Shuang Chen,Michelle H. Wong,Atilla Yilmaz,Anatoly Slepenkin,Danica J. Schulte,Randa Alsabeh,Terence M. Doherty,Ellena M. Peterson,Andre E. Nel,Moshe Arditi +12 more
TL;DR: It is concluded that moderate, but not severe, pulmonary bacterial infection can induce allergic sensitization to inert inhaled antigens through a mechanism that requires MyD88-dependent DC activation and is controlled by Treg cells.