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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
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Journal ArticleDOI
Two-Wave Nanotherapy To Target the Stroma and Optimize Gemcitabine Delivery To a Human Pancreatic Cancer Model in Mice
Huan Meng,Yang Zhao,Juyao Dong,Min Xue,Yu Shen Lin,Zhaoxia Ji,Wilson X. Mai,Haiyuan Zhang,Chong Hyun Chang,C. Jeffrey Brinker,C. Jeffrey Brinker,Jeffrey I. Zink,Andre E. Nel +12 more
TL;DR: A two-wave approach provided effective shrinkage of the tumor xenografts beyond 25 days, compared to the treatment with free drug or gemcitabine-loaded liposomes only, and introduces the concept of using a stepwise engineered approach to address a range of biological impediments that interfere in nanocancer therapy in a spectrum of cancers.
Journal ArticleDOI
Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer
Xiangsheng Liu,Paulina Lin,Ian Perrett,Joshua Lin,Yu-Pei Liao,Chong Hyun Chang,Jinhong Jiang,Nanping Wu,Timothy R. Donahue,Zev A. Wainberg,Andre E. Nel,Huan Meng +11 more
TL;DR: It is demonstrated that iRGD enhances the efficacy of irinotecan-loaded silicasome–based therapy and may be a suitable adjuvant in nanoparticle-based treatments for PDAC.
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Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells.
Xiang Wang,Tian Xia,Susana Addo Ntim,Zhaoxia Ji,Saji George,Huan Meng,Haiyuan Zhang,Vincent Castranova,Somenath Mitra,Andre E. Nel +9 more
TL;DR: It is found that hydrophobicity is the major factor determining AP- and PD-MWCNT agglomeration in tissue culture media but that the ionic strength is the main factor determining COOH- MWCNT suspendability.
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The Fate of ZnO Nanoparticles Administered to Human Bronchial Epithelial Cells
TL;DR: Results corroborate a model for ZnO nanoparticle toxicity that is based on nanoparticle uptake followed by intracellular dissolution and suggest cellular uptake of ZNO nanoparticles is a mechanism of zinc accumulation in cells.
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Classification NanoSAR Development for Cytotoxicity of Metal Oxide Nanoparticles
TL;DR: It is important to recognize that a significantly larger data set would be needed in order to expand the applicability domain and increase the confidence and reliability of data-driven nanoSARs.