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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
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Journal ArticleDOI
Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes
TL;DR: Pro-oxidative interactions of clofazimine with human phagocytes may contribute to the intraphagocytic antimycobacterial activity of this agent.
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Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape.
Andre E. Nel,Jeff F. Miller +1 more
TL;DR: In this article, the authors present a forward-looking perspective of how vaccine design can be adapted to improve durability of the immune response and vaccine adaptation to overcome immune escape by viral variants.
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Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy.
Xiangsheng Liu,Jinhong Jiang,Chong Hyun Chang,Yu-Pei Liao,Jared J. Lodico,Ivanna Tang,Emily Zheng,Waveley Qiu,Matthew Lin,Xiang Wang,Ying Ji,Kuo-Ching Mei,Andre E. Nel,Huan Meng +13 more
TL;DR: A mesoporous silica nanoparticle (MSNP) based platform is developed for high-dose loading of a range of activated platinum (Pt) chemo agents that can be attached to the porous interior through the use of electrostatic and coordination chemistry under weak-basic pH conditions as discussed by the authors.
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The cellular impacts of diesel exhaust particles: beyond inflammation and death.
Ning Li,Andre E. Nel +1 more
TL;DR: Airway epithelial cells are at greater risk of DNA damage because of their constant exposure to PM-induced oxidative stress, and many polycyclic aromatic hydrocarbons associated with DEP are genotoxic as they form a PAH-DNA adduct.
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Part II: coordinated biosensors--development of enhanced nanobiosensors for biological and medical applications.
TL;DR: This review describes several biosensors developed for detecting biologically relevant compounds, including those for hydrogen peroxide, dopamine, glucose, DNA and cytochrome C, and highlights the potential advantages of using nanoscale biosensor systems.