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Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
Papers
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Journal Article
Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.
TL;DR: The importance of C-kinase was substantiated by the ability of 1-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H7), a potent inhibitor of this enzyme, to interfere with IL-2 receptor expression and cellular [methyl-3H]thymidine uptake during primary activation.
Journal Article
Primary Human CD4+ T Cells Contain Heterogeneous IκB Kinase Complexes: Role in Activation of the IL-2 Promoter
Ali Khoshnan,Stephan J. Kempiak,Brydon L. Bennett,David Bae,Weiming Xu,Anthony M. Manning,Carl H. June,Andre E. Nel +7 more
TL;DR: The presence of an IKK beta-mediated signaling pathway that is activated by TCR and CD28 coligation and regulates IL-2 promoter activity is demonstrated.
Journal ArticleDOI
Environmental Impacts by Fragments Released from Nanoenabled Products: A Multiassay, Multimaterial Exploration by the SUN Approach
Mónica J.B. Amorim,Sijie Lin,Sijie Lin,Karsten Schlich,José M. Navas,Andrea Brunelli,Nicole Neubauer,Klaus Vilsmeier,Anna Luisa Costa,Andreas Gondikas,Tian Xia,Liliana Galbis,Elena Badetti,Antonio Marcomini,Danail Hristozov,Frank von der Kammer,Kerstin Hund-Rinke,Janeck J. Scott-Fordsmand,Andre E. Nel,Wendel Wohlleben +19 more
TL;DR: The results support NEPs grouping by the matrix material regarding ecotoxicological effect during the use phase, and the possible modulation of ecotoxicity by nanomaterial additives in plastics/polymer/cement, finding none.
Journal ArticleDOI
Accurate quantitation of native Gc in serum and estimation of endogenous Gc: G-actin complexes by rocket immunoelectrophoresis.
Pascal J. Goldschmidt-Clermont,Robert M. Galbraith,David L. Emerson,Philip A.M. Werner,Andre E. Nel,William M. Lee +5 more
TL;DR: The results show that rocket immunoelectrophoresis can be modified to provide accurate Gc levels, and also information concerning different molecular forms of this protein.
Patent
Cationic polymer coated mesoporous silica nanoparticles and uses thereof
Jeffrey I. Zink,Andre E. Nel,Tian Xia,Zhaoxia Ji,Huan Meng,Zongxi Li,Monty Liong,Min Xue,Derrick Tarn +8 more
TL;DR: In this paper, a submicron structure with a silica body defining a plurality of pores is described, where an oligonucleotide and a therapeutic agent are used to deliver the therapeutic agent to a cell.