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Natalie C. Butterfield
Researcher at Imperial College London
Publications - 34
Citations - 1857
Natalie C. Butterfield is an academic researcher from Imperial College London. The author has contributed to research in topics: Gene & Limb development. The author has an hindex of 14, co-authored 32 publications receiving 1195 citations. Previous affiliations of Natalie C. Butterfield include University of Queensland & Harvard University.
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Journal ArticleDOI
An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris,John P. Kemp,John P. Kemp,Scott E. Youlten,Laetitia Laurent,John G. Logan,Ryan C. Chai,Nicholas A. Vulpescu,Vincenzo Forgetta,Aaron Kleinman,Sindhu T. Mohanty,C. Marcelo Sergio,Julian M.W. Quinn,Loan Nguyen-Yamamoto,Aimee Lee Luco,Jinchu Vijay,Marie-Michelle Simon,Albena Pramatarova,Carolina Medina-Gomez,Katerina Trajanoska,Elena J. Ghirardello,Natalie C. Butterfield,Katharine F. Curry,Victoria D. Leitch,Penny C. Sparkes,Anne-Tounsia Adoum,Naila S. Mannan,Davide Komla-Ebri,Andrea S. Pollard,Hannah F. Dewhurst,Thomas A D Hassall,Michael-John G. Beltejar,Douglas J. Adams,Suzanne M. Vaillancourt,Stephen Kaptoge,Paul A. Baldock,Cyrus Cooper,Cyrus Cooper,Cyrus Cooper,Jonathan Reeve,Evangelia E. Ntzani,Evangelia E. Ntzani,Evangelos Evangelou,Evangelos Evangelou,Claes Ohlsson,David Karasik,Fernando Rivadeneira,Douglas P. Kiel,Jonathan H Tobias,Celia L Gregson,Nicholas C. Harvey,Nicholas C. Harvey,Elin Grundberg,Elin Grundberg,David Goltzman,David J. Adams,Christopher J. Lelliott,David A. Hinds,Cheryl L. Ackert-Bicknell,Yi-Hsiang Hsu,Matthew T. Maurano,Peter I. Croucher,Graham R. Williams,J. H. Duncan Bassett,David M. Evans,David M. Evans,J. Brent Richards +66 more
TL;DR: This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.
Journal ArticleDOI
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
John P. Kemp,John P. Kemp,John A. Morris,Carolina Medina-Gomez,Vincenzo Forgetta,Nicole M. Warrington,Nicole M. Warrington,Scott E. Youlten,Scott E. Youlten,Jie Zheng,Celia L Gregson,Elin Grundberg,Katerina Trajanoska,John G. Logan,Andrea S. Pollard,Penny C. Sparkes,Elena J. Ghirardello,Rebecca Allen,Victoria D. Leitch,Natalie C. Butterfield,Davide Komla-Ebri,Anne-Tounsia Adoum,Katharine F. Curry,Jacqueline K. White,Fiona Kussy,Keelin M Greenlaw,ChangJiang Xu,Nicholas C. Harvey,Nicholas C. Harvey,Cyrus Cooper,Cyrus Cooper,Cyrus Cooper,David J. Adams,Celia M. T. Greenwood,Matthew T. Maurano,Stephen Kaptoge,Fernando Rivadeneira,Jonathan H Tobias,Peter I. Croucher,Peter I. Croucher,Cheryl L. Ackert-Bicknell,J. H. Duncan Bassett,Graham R. Williams,J. Brent Richards,J. Brent Richards,David M. Evans,David M. Evans +46 more
TL;DR: The results implicate GPC6 as a novel determinant of BMD, and also identify abnormal skeletal phenotypes in knockout mice associated with a further 100 prioritized genes.
Journal ArticleDOI
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Michelle M. McDonald,Michelle M. McDonald,Weng Hua Khoo,Weng Hua Khoo,Pei Ying Ng,Ya Xiao,Jad Zamerli,Peter Thatcher,Wunna Kyaw,Karrnan Pathmanandavel,Abigail K. Grootveld,Imogen Moran,Danyal Butt,Akira Nguyen,Alexander P. Corr,Alexander P. Corr,Sean C. Warren,Maté Biro,Natalie C. Butterfield,Siobhan E. Guilfoyle,Davide Komla-Ebri,Michael R.G. Dack,Hannah F. Dewhurst,John G. Logan,Yongxiao Li,Sindhu T. Mohanty,Sindhu T. Mohanty,Niall M. Byrne,Niall M. Byrne,Rachael L. Terry,Rachael L. Terry,Marija K. Simic,Marija K. Simic,Ryan C. Chai,Julian M.W. Quinn,Julian M.W. Quinn,Scott E. Youlten,Jessica A. Pettitt,David Abi-Hanna,David Abi-Hanna,Rohit Jain,Rohit Jain,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger,Mischa Lundberg,Mischa Lundberg,Shuting Sun,F H Ebetino,Paul Timpson,Woei Ming Lee,Paul A. Baldock,Paul A. Baldock,Michael J. Rogers,Michael J. Rogers,Robert Brink,Robert Brink,Graham R. Williams,J. H. Duncan Bassett,John P. Kemp,John P. Kemp,Nathan J. Pavlos,Peter I. Croucher,Peter I. Croucher,Tri Giang Phan,Tri Giang Phan +65 more
TL;DR: This article showed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and express a number of non-canonical osteoclast genes that are associated with structural and functional bone phenotypes when deleted in mice.
Journal ArticleDOI
A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development
Alyson Ashe,Daniel K. Morgan,Daniel K. Morgan,Nadia C Whitelaw,Nadia C Whitelaw,Timothy J. C. Bruxner,Nicola Vickaryous,Liza L Cox,Natalie C. Butterfield,Carol Wicking,Marnie E. Blewitt,Sarah J. Wilkins,Gregory J. Anderson,Timothy C. Cox,Emma Whitelaw +14 more
TL;DR: It is shown that all ten MommeDs link to unique sites in the genome, that homozygosity for the mutations is associated with severe developmental abnormalities and that heterozygosity results in phenotypic abnormalities and reduced reproductive fitness in some cases.
Journal ArticleDOI
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies
Alyson Ashe,Natalie C. Butterfield,Liam Town,Andrew D. Courtney,Ashley N. Cooper,Charles Ferguson,Rachael Barry,Fredrik Olsson,Karel F. Liem,Robert G. Parton,Brandon J. Wainwright,Kathryn V. Anderson,Emma Whitelaw,Carol Wicking +13 more
TL;DR: An N-ethyl-N-nitrosourea-derived mouse mutant with a hypomorphic missense mutation in the IFT144 gene is described, which phenocopies a number of the skeletal and craniofacial anomalies seen in patients with human skeletal ciliopathies.