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Andy G.X. Zeng
Researcher at Princess Margaret Cancer Centre
Publications - 26
Citations - 302
Andy G.X. Zeng is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 3, co-authored 11 publications receiving 58 citations. Previous affiliations of Andy G.X. Zeng include University of Toronto.
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Journal ArticleDOI
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
Stephanie Z. Xie,Laura García-Prat,Veronique Voisin,Robin Ferrari,Olga I. Gan,Elvin Wagenblast,Kerstin B. Kaufmann,Andy G.X. Zeng,Andy G.X. Zeng,Shin-ichiro Takayanagi,Ishita Patel,Esther K. Lee,Joseph Jargstorf,Gareth Holmes,Guy Romm,Kristele Pan,Michelle Shoong,Aditi Vedi,Chiara Luberto,Mark D. Minden,Gary D. Bader,Elisa Laurenti,John E. Dick,John E. Dick +23 more
TL;DR: This work identifies a linkage between sphingolipid metabolism, proteostatic quality control systems, and HSC self-renewal and provides therapeutic targets for improving HSC-based cellular therapeutics.
Journal ArticleDOI
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Lindsey E. Montefiori,Sonja Bendig,Zhaohui Gu,Xiao-Long Chen,Petri Pölönen,Xiaotu Ma,Alex Murison,Andy G.X. Zeng,Laura García-Prat,Kirsten Dickerson,Ilaria Iacobucci,Sherif Abdelhamed,Ryan Hiltenbrand,Paul E. Mead,Cyrus M. Mehr,Beisi Xu,Zhongshan Cheng,Ti-Cheng Chang,Tamara Westover,Jing Ma,Anna Stengel,Shunsuke Kimura,Chunxu Qu,Marcus B. Valentine,Marissa Rashkovan,Selina M. Luger,Mark R. Litzow,Jacob M. Rowe,Monique L. den Boer,Victoria Wang,Jun Yin,Steven M. Kornblau,Stephen P. Hunger,Mignon L. Loh,Ching-Hon Pui,Wenjian Yang,Kristine R. Crews,Kathryn G. Roberts,Jun J. Yang,Mary V. Relling,William E. Evans,Wendy Stock,Elisabeth Paietta,Adolfo A. Ferrando,Jinghui Zhang,Wolfgang Kern,Torsten Haferlach,Gang Wu,John E. Dick,Jeffery M. Klco,Claudia Haferlach,Charles G. Mullighan +51 more
TL;DR: In this paper, the authors describe a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid, and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.
Journal ArticleDOI
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia
Andy G.X. Zeng,Suraj Bansal,Liqing Jin,Amanda Mitchell,Weihsu Claire Chen,Hussein A. Abbas,Michelle Chan-Seng-Yue,Veronique Voisin,Peter van Galen,Anne Tierens,Meyling Cheok,Claude Preudhomme,Hervé Dombret,Naval Daver,P. Andrew Futreal,Mark D. Minden,James A. Kennedy,Jean C.Y. Wang,John E. Dick +18 more
TL;DR: In this paper , the authors determined the leukemia cell hierarchy makeup from bulk transcriptomes of more than 1,000 patients through deconvolution using single-cell reference profiles of leukemia stem, progenitor and mature cell types.
Journal ArticleDOI
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate.
Laura García-Prat,Laura García-Prat,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Florin Schneiter,Veronique Voisin,Alex Murison,Alex Murison,Jocelyn Chen,Jocelyn Chen,Michelle Chan-Seng-Yue,Michelle Chan-Seng-Yue,Olga I. Gan,Olga I. Gan,Jessica McLeod,Jessica McLeod,Sabrina A. Smith,Sabrina A. Smith,Michelle C. Shoong,Michelle C. Shoong,Darrien Parris,Darrien Parris,Kristele Pan,Kristele Pan,Andy G.X. Zeng,Andy G.X. Zeng,Gabriela Krivdova,Gabriela Krivdova,Kinam Gupta,Kinam Gupta,Shin-Ichiro Takayanagi,Shin-Ichiro Takayanagi,Elvin Wagenblast,Elvin Wagenblast,Weijia Wang,Mathieu Lupien,Mathieu Lupien,Mathieu Lupien,Timm Schroeder,Stephanie Z. Xie,Stephanie Z. Xie,John E. Dick,John E. Dick,John E. Dick +43 more
TL;DR: In this paper, the authors show that lysosomes, sophisticated nutrient-sensing and signaling centers, are regulated dichotomously by transcription factor EB (TFEB) and MYC to balance catabolic and anabolic processes required for activating LT-HSCs and guiding their lineage fate.
Journal ArticleDOI
Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Stephanie Z. Xie,Kerstin B. Kaufmann,Weijia Wang,Michelle Chan-Seng-Yue,Michelle Chan-Seng-Yue,Olga I. Gan,Elisa Laurenti,Elisa Laurenti,Laura García-Prat,Shin-ichiro Takayanagi,Stanley W.K. Ng,Changjiang Xu,Andy G.X. Zeng,Andy G.X. Zeng,Liqing Jin,Jessica McLeod,Elvin Wagenblast,Amanda Mitchell,James A. Kennedy,James A. Kennedy,James A. Kennedy,Qiang Liu,Héléna Boutzen,Melissa Kleinau,Joseph Jargstorf,Gareth Holmes,Yang Zhang,Veronique Voisin,Gary D. Bader,Jean C.Y. Wang,Jean C.Y. Wang,Jean C.Y. Wang,Yusuf A. Hannun,Chiara Luberto,Timm Schroeder,Mark D. Minden,John E. Dick,John E. Dick +37 more
TL;DR: It is shown that S1PR3, a receptor for the bioactive lipid sphingosine-1-phosphate, is a central regulator which drives myeloid differentiation and activates inflammatory programs in both HSC and LSC.