Anna Lena Cremer

TL;DR: It is shown that browning by TH requires TH-receptor β and occurs independently of the sympathetic nervous system, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents.

TL;DR: This work combined fMRI and a novel [11C]raclopride PET method to assess systems-level activation and dopamine release in response to palatable food intake in humans and identified immediate orosensory and delayed post-ingestive dopamine release.

TL;DR: It is demonstrated that glucagon-like peptide (GLP)-1 inhibits glucose uptake and promotes β-oxidation in cultured astrocytes, and lack of GLP-1R signaling mounts an adaptive stress response resulting in an improvement of systemic glucose homeostasis and memory formation.

TL;DR: In this paper, intersectional genetic manipulations were employed to probe the feeding and glucoregulatory function of distinct sensory neurons, and it was shown that distinct gut-innervating sensory neurons differentially control feeding and glucose neurocircuits and may provide specific targets for metabolic control.

TL;DR: Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined, and PNOCARC neurons are characterized as a novel ARC neuron population activated upon palatable food consumption to promote hyperphags.