A
Arezou A. Ghazani
Researcher at Harvard University
Publications - 33
Citations - 6864
Arezou A. Ghazani is an academic researcher from Harvard University. The author has contributed to research in topics: Germline & Germline mutation. The author has an hindex of 18, co-authored 29 publications receiving 6154 citations. Previous affiliations of Arezou A. Ghazani include Ontario Institute for Cancer Research & University of Toronto.
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Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Assessing the Effect of Surface Chemistry on Gold Nanorod Uptake, Toxicity, and Gene Expression in Mammalian Cells
TL;DR: Results indicate that gold nanorods are well suited for therapeutic applications, such as thermal cancer therapy, due to their tunable cell uptake and low toxicity.
Journal ArticleDOI
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium
Laura M. Amendola,Gail P. Jarvik,Michael C. Leo,Heather M. McLaughlin,Yassmine Akkari,Michelle D. Amaral,Jonathan S. Berg,Sawona Biswas,Kevin M. Bowling,Laura K. Conlin,Greg M. Cooper,Michael O. Dorschner,Matthew C. Dulik,Arezou A. Ghazani,Rajarshi Ghosh,Robert C. Green,Robert C. Green,Robert C. Green,Ragan Hart,Carrie Horton,Jennifer J. Johnston,Matthew S. Lebo,Matthew S. Lebo,Aleksandar Milosavljevic,Jeffrey Ou,Christine Pak,Ronak Y. Patel,Sumit Punj,Carolyn Sue Richards,Joseph Salama,Natasha T. Strande,Yaping Yang,Sharon E. Plon,Leslie G. Biesecker,Heidi L. Rehm,Heidi L. Rehm,Heidi L. Rehm +36 more
TL;DR: Although an initial pilot of the ACMG-AMP guidelines did not lead to increased concordance in variant interpretation, comparing variant interpretations to identify differences and having a common framework to facilitate resolution of those differences were beneficial for improving agreement, allowing iterative movement toward increased reporting consistency for variants in genes associated with monogenic disease.
Journal ArticleDOI
Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
David Issadore,Jaehoon Chung,Huilin Shao,Monty Liong,Arezou A. Ghazani,Cesar M. Castro,Ralph Weissleder,Hakho Lee +7 more
TL;DR: A miniature device that combines microfluidics and magnets to measure CTCs in patient blood at single-cell resolution and appears to be a more sensitive cell counter than existing devices, with the potential to change patient management and disease monitoring in the clinic.
Journal ArticleDOI
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Andrew J. Aguirre,Jonathan A. Nowak,Jonathan A. Nowak,Nicholas D. Camarda,Richard A. Moffitt,Arezou A. Ghazani,Arezou A. Ghazani,Arezou A. Ghazani,Mehlika Hazar-Rethinam,Srivatsan Raghavan,Jaegil Kim,Lauren K. Brais,Dorisanne Y. Ragon,Marisa W. Welch,Emma Reilly,Devin McCabe,Lori Marini,Lori Marini,Kristin Anderka,Karla Helvie,Karla Helvie,Nelly Oliver,Nelly Oliver,Ana Babic,Annacarolina da Silva,Annacarolina da Silva,Brandon Nadres,Emily E. Van Seventer,Heather A. Shahzade,Joseph P. St. Pierre,Kelly P. Burke,Kelly P. Burke,Thomas E. Clancy,Thomas E. Clancy,James M. Cleary,James M. Cleary,Leona A. Doyle,Leona A. Doyle,Kunal Jajoo,Kunal Jajoo,Nadine Jackson McCleary,Nadine Jackson McCleary,Jeffrey A. Meyerhardt,Jeffrey A. Meyerhardt,Janet E. Murphy,Kimmie Ng,Kimmie Ng,Anuj K. Patel,Anuj K. Patel,Kimberly Perez,Kimberly Perez,Michael H. Rosenthal,Michael H. Rosenthal,Douglas A. Rubinson,Douglas A. Rubinson,Marvin Ryou,Marvin Ryou,Geoffrey I. Shapiro,Geoffrey I. Shapiro,Ewa Sicinska,Stuart G. Silverman,Stuart G. Silverman,Rebecca J. Nagy,Richard B. Lanman,Deborah Knoerzer,Dean Welsch,Matthew B. Yurgelun,Matthew B. Yurgelun,Charles S. Fuchs,Levi A. Garraway,Gad Getz,Gad Getz,Jason L. Hornick,Jason L. Hornick,Bruce E. Johnson,Matthew H. Kulke,Matthew H. Kulke,Robert J. Mayer,Robert J. Mayer,Jeffrey W. Miller,Paul B. Shyn,Paul B. Shyn,David A. Tuveson,Nikhil Wagle,Jen Jen Yeh,William C. Hahn,Ryan B. Corcoran,Scott L. Carter,Brian M. Wolpin,Brian M. Wolpin +89 more
TL;DR: Using an integrated multidisciplinary biopsy program, it is demonstrated that real-time genomic characterization of advanced PDAC can identify clinically relevant alterations that inform management of this difficult disease.