Athanasios Ziogas

TL;DR: The findings identify a novel and therapeutically relevant anti-tumor facet of trained immunity involving appropriate rewiring of granulopoiesis, which is transmissible by bone marrow transplantation to recipient naive mice.

TL;DR: It is shown that IL-17 downregulates human endothelial cell expression of Del-1 by targeting a critical transcription factor, C/EBPβ, and resolvin-D1 (RvD1) confers protection againstIL-17-driven periodontal bone loss in a Del- 1-dependent manner, indicating an RvD 1-Del-1 axis against IL- 17-induced pathological inflammation.

TL;DR: It is found that Del-1 was expressed by several cellular components of the HSC niche, including arteriolar endothelial cells, CXCL12-abundant reticular cells, and cells of the osteoblastic lineage, which represents a juxtacrine homeostatic adaptation of the hematopoietic system in stress myelopoiesis.

TL;DR: It is shown that DHEA reduces microglia-mediated inflammation in an acute lipopolysaccharide-induced neuro-inflammation model in mice and in culturedmicroglia in vitro, providing the platform for potential future therapeutic interventions in neuro-inflammatory pathologies.

TL;DR: The findings show that adipocyte HIF2α is protective against maladaptation to obesity and metabolic dysregulation by promoting angiogenesis in both WAT and BAT and by counteracting obesity-mediated BAT dysfunction.