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Ayyakkannu Ayyanan
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 14
Citations - 9246
Ayyakkannu Ayyanan is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Breast cancer & Stem cell. The author has an hindex of 9, co-authored 12 publications receiving 8466 citations. Previous affiliations of Ayyakkannu Ayyanan include ISREC & University of Reims Champagne-Ardenne.
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Journal ArticleDOI
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
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Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
Manfred Beleut,Renuga Devi Rajaram,Marian Caikovski,Ayyakkannu Ayyanan,Davide Germano,Yongwon Choi,Pascal Schneider,Cathrin Brisken +7 more
TL;DR: It is shown that in the adult female, progesterone drives proliferation of MECs in two waves and elicits proliferation by a cell-intrinsic and a paracrine mechanism.
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Epithelial‐Mesenchymal Transition‐Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells
Venkata Lokesh Battula,Kurt W. Evans,Brett G. Hollier,Yuexi Shi,Frank C. Marini,Ayyakkannu Ayyanan,Rui Yu Wang,Cathrin Brisken,Rudy Guerra,Michael Andreeff,Sendurai A. Mani +10 more
TL;DR: It is demonstrated that the EMT‐derived cells are similar to MSCs in gene expression, multilineage differentiation, and ability to migrate towards tumor cells and wound sites.
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Progesterone/RANKL is a major regulatory axis in the human breast.
Tamara Tanos,George Sflomos,Pablo Christian Echeverria,Ayyakkannu Ayyanan,Maria Gutierrez,Jean-François Delaloye,Wassim Raffoul,Maryse Fiche,William C. Dougall,Pascal Schneider,Ozden Yalcin-Ozuysal,Cathrin Brisken +11 more
TL;DR: Ex vivo model identifies the progesterone/RANKL axis as an important proliferative stimulus in the human breast and finds that important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention.
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A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
George Sflomos,Valérian Dormoy,Tauno Metsalu,Rachel Jeitziner,Laura Battista,Valentina Scabia,Wassim Raffoul,Jean-François Delaloye,Assya Treboux,Maryse Fiche,Jaak Vilo,Ayyakkannu Ayyanan,Cathrin Brisken +12 more
TL;DR: It is shown that the traditional grafting of ER⁺ tumor cells into mammary fat pads induces TGFβ/SLUG signaling and basal differentiation when they require low SLUG levels to grow in vivo.