Showing papers by "Baoshun Liu published in 2022"
TL;DR: In this article , a double-layered nanotube morphology was used to simultaneously create surface oxygen vacancies and interface heterojunctions on CeO2 with a single-step Fe doping engineering.
10 citations
TL;DR: In this paper , a polyvinylpyrrolidone-assist kinetic-control strategy was proposed to achieve the "anti-epitaxial growth" pattern of foreign MOF nucleus on the (111) facets of UiO-66-NH 2 ǫ octahedron seed.
Abstract: MOF-on-MOF heterostructure is attractive in material science because of its potential synergistic effect in catalysis. However, precisely control the growth pattern at the MOF nucleation stage to simultaneously manipulate the metallic composition and structure dimensionality remain as a challenge work. Herein, we introduce a polyvinylpyrrolidone-assist kinetic-control strategy to achieve the "anti-epitaxial growth" pattern of foreign MOF nucleus on the (111) facets of UiO-66-NH 2 octahedron seed, and successfully construct diverse two dimensional-on-three dimensional (2D-on-3D) MOF heterostructures (2D-on-3D Cu, Zn, Cd, Co, and Ni). Notably, the 2D-on-3D Cu exhibits unique "dimensionality-hybrid" effect in photocatalysis which led to a significant photoactivity enhancement than those of the traditional "dimensionality-identical" 2D, 3D and 3D-on-3D MOF structures.
10 citations
TL;DR: In this paper , a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane was presented.
Abstract: Abstract Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co 2+ , which results in the downregulation of HSP90 expression and the inhibition of cellular heat resistance, thereby improving the photothermal therapy effect of PDA. H 2 S secretion after the enzymatic hydrolysis of ADT leads to high-concentration gas therapy. Moreover, ADT changes the balance between nicotinamide adenine dinucleotide/flavin adenine dinucleotide (NADH/FAD) during tumour glycolysis. ATP synthesis is limited by NADH consumption, which triggers a certain degree of tumour growth inhibition and results in starvation therapy. Potentiated 2D/3D autofluorescence imaging of NADH/FAD is also achieved in liquid nitrogen and employed to efficiently monitor tumour therapy. The developed biomimetic nanoplatform provides an approach to treat orthotopic tumours and inhibit metastasis.
9 citations
TL;DR: In this paper , a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane was presented.
Abstract: Abstract Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co 2+ , which results in the downregulation of HSP90 expression and the inhibition of cellular heat resistance, thereby improving the photothermal therapy effect of PDA. H 2 S secretion after the enzymatic hydrolysis of ADT leads to high-concentration gas therapy. Moreover, ADT changes the balance between nicotinamide adenine dinucleotide/flavin adenine dinucleotide (NADH/FAD) during tumour glycolysis. ATP synthesis is limited by NADH consumption, which triggers a certain degree of tumour growth inhibition and results in starvation therapy. Potentiated 2D/3D autofluorescence imaging of NADH/FAD is also achieved in liquid nitrogen and employed to efficiently monitor tumour therapy. The developed biomimetic nanoplatform provides an approach to treat orthotopic tumours and inhibit metastasis.
9 citations
TL;DR: In this paper , a transition metal doping is used to improve the phase-change random access memory (PCRAM) properties, while the underlying mechanism remains to be sufficiently investigated, a Cr-doped Sb2Te film is fabricated by co-sputtering and the enhancement mechanism of Cr doping is deeply investigated by experiments.
7 citations
01 Jun 2022
TL;DR: In this paper , two novel aggregation-induced emission luminogens (AIEgens) were designed by integrating the advantages of triphenylamine (TPA) and phenanthroimidazole (PI), which exhibited excellent electron-donating ability of TPA and bipolar characteristics and suitable carrier transporting ability of PI.
Abstract: Aggregation-induced emission (AIE) offers a solution to harvest strong solid-state fluorescence, which is crucial to achieving efficient organic light-emitting diodes (OLEDs). In this study, two novel AIE luminogens (AIEgens) were designed by integrating the advantages of triphenylamine (TPA) and phenanthroimidazole (PI), which exhibited excellent electron-donating ability of TPA and bipolar characteristics and suitable carrier transporting ability of PI. The two structural units were connected by a π bridge of tris/tetrastyrene group with a different number of benzene rings. Intra-/inter-molecular charge transfer can be obtained by adjusting the conjugation of the π bridge, and the AIE activity is also manipulated accordingly. The dilute solutions of TPE-TPAPPI present concentration- and polarity-dependent emission, demonstrating emission Adjustability by controlling the ratio of intramolecular and intermolecular charge transfer. It is found that intermolecular charge transfer dominates in film state. A non-doped OLED based on TPE-TPAPPI shows a maximum external quantum efficiency (EQE) of 4.01% with a low turn-on voltage of 3.2 V. The efficiency roll-off is only 4.75% even at a high brightness of 1000 cd m−2, demonstrating the superiority of our AIEgens in OLED application.
6 citations
TL;DR: In this paper , a comparison-matching small-angle neutron scattering (CM-SANS) was used to evaluate the pore accessibility of marine shale samples from Wufeng-Longmaxi shale, revealing the relationship between wettability and pore connectivity.
6 citations
TL;DR: A novel, traceless strategy to enable the facile and efficient one-step synthesis of site-specific antibody-drug conjugates (ADCs) by harnessing a thioester-based acyl transfer reagent.
Abstract: Direct chemical modification of native antibodies in a site-specific manner remains a great challenge due to the complicated structural characteristics of antibodies. Ligand-directed conjugation can achieve the selective modification of antibodies, but usually requires multiple extra steps for ligand release and cargo assembly. Herein, we report a novel, traceless strategy to enable the facile and efficient one-step synthesis of site-specific antibody-drug conjugates (ADCs) by harnessing a thioester-based acyl transfer reagent. The designed reagent, consisting of an optimized Fc-targeting ligand, a thioester bridge and a toxin payload, directly assembles the toxin precisely onto the K251 position of native IgGs and simultaneously self-releases the affinity ligand in one step. With this traceless, one-step method, we successfully synthesized a series of K251-linked ADCs from native Trastuzumab. These ADCs demonstrated excellent homogeneity, thermal stability, and both in vitro and in vivo anti-tumor activity. This strategy is equally efficient for IgG1, IgG2, and IgG4 subtypes. The current work presents a robust, traceless, site-specific antibody functionalization via a self-releasing strategy, and offers a novel acyl transfer design for broad potential application in ligand-directed protein modifications.
6 citations
TL;DR: This method provides a sustainable access to α-hydroxyphosphine oxides in up to 88% yield with good functional group compatibility under mild and neutral conditions and afforded α-phosphinylated cyclic ethers in good overall yields.
Abstract: A photocatalyst- and additive-free visible-light-induced α-C(sp3)-H phosphinylation of unactivated ethers involving a C-O bond cleavage with molecular oxygen as the sole oxidant at room temperature has been achieved. This method provides a sustainable access to α-hydroxyphosphine oxides in up to 88% yield with good functional group compatibility under mild and neutral conditions (34 examples). Moreover, the subsequent two-step conversion of the resulting dihydroxy diarylphosphine oxides afforded α-phosphinylated cyclic ethers in good overall yields (10 examples).
5 citations
TL;DR: Based on ascorbyl palmitate (PA) and l-arginine (l-Arg), a multifunctional nanocarrier is designed for synergetic treatment of tumor with photothermal and nitric oxide (NO) gas therapy as mentioned in this paper .
5 citations
TL;DR: A Kinect V2-based visual method to solve the human dependence on the yarn bobbin robot in the grabbing operation and shows that the average working time of the robot system is within 10 s, and the grasping success rate is above 80%, which meets the industrial production requirements.
Abstract: This work proposes a Kinect V2-based visual method to solve the human dependence on the yarn bobbin robot in the grabbing operation. In this new method, a Kinect V2 camera is used to produce three-dimensional (3D) yarn-bobbin point cloud data for the robot in a work scenario. After removing the noise point cloud through a proper filtering process, the M-estimator sample consensus (MSAC) algorithm is employed to find the fitting plane of the 3D cloud data; then, the principal component analysis (PCA) is adopted to roughly register the template point cloud and the yarn-bobbin point cloud to define the initial position of the yarn bobbin. Lastly, the iterative closest point (ICP) algorithm is used to achieve precise registration of the 3D cloud data to determine the precise pose of the yarn bobbin. To evaluate the performance of the proposed method, an experimental platform is developed to validate the grabbing operation of the yarn bobbin robot in different scenarios. The analysis results show that the average working time of the robot system is within 10 s, and the grasping success rate is above 80%, which meets the industrial production requirements.
TL;DR: In this article , the Cs3Cu2I5 single crystals (SCs) were prepared by the solution-processed method and the emission band at 440 nm with an average decay time of 595 ns under X-ray excitation was measured.
Abstract: Perovskite scintillators have become increasingly popular in recent years because of their simple production and high sensitivity to X-ray. Due to large Stokes shifts, high light yield, eco-friendly fabrication, and good stability, the lead-free Cu-based perovskites have gained much attention. In this paper, we prepared the Cs3Cu2I5 single crystals (SCs) by the solution-processed method. At room temperature, we measured the emission band at 440 nm with an average decay time of 595 ns under X-ray excitation. Under 137Cs γ-ray excitation, we determined that the light yield of Cs3Cu2I5 SCs was 23 000 photons/MeV. Notably, under alpha particle excitation by 241Am, the light yield of Cs3Cu2I5 SCs is approximately 3.2 times higher than that of the commercial scintillator LYSO(Ce). In addition, we systematically investigated the cryogenic scintillation properties of Cs3Cu2I5 SCs at the temperature range of 60-300 K. With decreasing temperature, the intensity of the emission band at 440 nm significantly increases, and an additional emission band at 336 nm emerges below 100 K. Meanwhile, the temperature-dependent decay times were determined. The fast and slow decay time of Cs3Cu2I5 SCs are estimated to be 221 and 1193 ns, respectively, at 60 K. Our findings highlight the great potential for Cs3Cu2I5 SCs to be a cryogenic scintillator.
TL;DR: In this article , the optical/color contrast of Sb2Te phase change material and its structural volution was investigated, and it was found that Sb 2Te film possesses high optical and color contrast owing to its high discrepancy of refractive index and extinction coefficient between as-deposited and crystalline states.
TL;DR: In this article , a two-component dual C-H activation macrocyclization strategy with an in situ-generated directing group was proposed to synthesize macrolactams with potent anti-Flu (H1N1) activity with no overt cytotoxic effects.
Abstract: •Rh(III)-catalyzed dual C–H multicomponent coupling and macrocyclization •Biomimetic modularization strategy promotes rapid discovery of lead compounds •Dual C–H macrocyclization is compatible with various reaction coupling •Access to novel macrocyclic oxime inhibitor of influenza H1N1 Herein, we describe a practical streamlined two-component dual C–H activation macrocyclization strategy entailing an in situ-generated directing group. The reaction mode is based on Rh(III)-catalyzed three-component coupling involving cascade C(sp3)–H/C(sp2)–H bond dual activation. The process is facilitated by readily obtainable amidation reagents, namely, aryl-substituted 1,4,2-dioxazol-5-ones, which can be transformed into amide directing groups via a rhodium-nitrene intermediate. DFT calculations revealed that the C–N versus C–C bond formation chemoselectivity was highly controllable. The synthetic utility of this multicomponent reaction is highlighted by the late-stage C–H functionalization of various complex natural macrocyclic compounds, triterpenoids, biologically active molecules, and drugs. Moreover, the developed method enables the expedient and diversified synthesis of complex macrolactams, and phenotypic screening indicated several unique oxime-containing macrolactams accessed via this strategy showing potent anti-Flu (H1N1) activity with no overt cytotoxic effects. Herein, we describe a practical streamlined two-component dual C–H activation macrocyclization strategy entailing an in situ-generated directing group. The reaction mode is based on Rh(III)-catalyzed three-component coupling involving cascade C(sp3)–H/C(sp2)–H bond dual activation. The process is facilitated by readily obtainable amidation reagents, namely, aryl-substituted 1,4,2-dioxazol-5-ones, which can be transformed into amide directing groups via a rhodium-nitrene intermediate. DFT calculations revealed that the C–N versus C–C bond formation chemoselectivity was highly controllable. The synthetic utility of this multicomponent reaction is highlighted by the late-stage C–H functionalization of various complex natural macrocyclic compounds, triterpenoids, biologically active molecules, and drugs. Moreover, the developed method enables the expedient and diversified synthesis of complex macrolactams, and phenotypic screening indicated several unique oxime-containing macrolactams accessed via this strategy showing potent anti-Flu (H1N1) activity with no overt cytotoxic effects.
01 Jan 2022-Journal of Materials Chemistry C. Materials for Optical, Magnetic and Electronic Devices
TL;DR: The development and utilization of organic persistent room-temperature phosphorescence (pRTP) materials have shown potential advantages in stimuli-responsive optoelectronic applications due to their long-lived lifetime and environmental sensitivity as discussed by the authors .
Abstract: Organic persistent room-temperature phosphorescence (pRTP) materials have shown potential advantages in stimuli-responsive optoelectronic applications due to their long-lived lifetime and environmental sensitivity. However, the development and utilization of pRTP materials...
TL;DR: The pathophysiological mechanism of oxidative stress in DFU is discussed, and identifiled natural biologics targeting these pathways to accelerate DFU healing are discussed in order to provide a new or potential direction for clinical treatment, nursing and related basic research of DFU.
Abstract: Difficult or even non-healing diabetic foot ulcers (DFU) are a global medical challenge. Although current treatments such as debridement, offloading, and infection control have resulted in partial improvement in DFU, the incidence, amputation, and mortality rates of DFU remain high. Therefore, there is an urgent need to find new or more effective drugs. Numerous studies have shown that oxidative stress plays an important role in the pathophysiology of DFU. The nuclear factor erythroid 2-related factor (Nrf2) signaling pathway and the advanced glycated end products (AGEs)-receptor for advanced glycation endproducts (RAGE), protein kinase C (PKC), polyol and hexosamine biochemical pathways play critical roles in the regulation of oxidative stress in the body. Targeting these pathways to restore redox balance can control and alleviate the occurrence and development of DFU. Natural biologics are a major source of potential drugs for these relevant targets, and their antioxidant potential has been extensively demonstrated. Here, we discussed the pathophysiological mechanism of oxidative stress in DFU, and identifiled natural biologics targeting these pathways to accelerate DFU healing, in order to provide a new or potential direction for clinical treatment, nursing and related basic research of DFU.
TL;DR: LiI-assisted surface chemistry to reduce Mg plating/stripping overpotential via in situ solubilization mechanism and ion conductive surface layer formation mechanism is reported in this article .
TL;DR: In this article , the Mott-Schottky junctions at the interface between the CeO2 semiconductors and the supported Pd metals were constructed, and the Ni dopants were introduced into the C2O2 lattices, thereby increasing the difference of Fermi level between the C 2O2 and Pd and further reducing the barrier of directional electron transfer from C 2 O2 to Pd.
Abstract: The eco-friendly and reusable heterogeneous Pd catalyst is an attractive alternative to the homogeneous Pd catalyst in the Suzuki reaction. However, the relatively low activity of heterogeneous Pd catalyst has become a major obstacle to its practical application. Herein, we construct the Mott-Schottky junctions at the interface between the CeO2 semiconductors and the supported Pd metals. Furthermore, the Ni dopants are introduced into the CeO2 lattices, thereby increasing the difference of Fermi level between CeO2 and Pd and further reducing the barrier of directional electron transfer from CeO2 to Pd. Meanwhile, the electronic structure of each element in the Pd/Ce1-xNixO2-δ is reconstructed by adjusting the Ni/Ce atomic ratio, so that the oxygen vacancy sites and the Ni sites act as electronic donors to induce the transfer of free electrons to the Pd. As a result, the electron-rich Pd/Ce0.9Ni0.1O2-δ catalysts exhibit high catalytic activity with a turnover frequency (TOF) value of 34,743 h−1 in Suzuki reactions.
TL;DR: In this paper , a simple pre-treatment of silicone foams with toluene immersion before irradiation was shown to remove the non-cross-linked oligomers that would interfere with the identification of degradation products.
TL;DR: In this paper , the presence of Na3Cit affects the asphaltene behavior at the oil-water interface, which enhances oilwater separation and, thereby, heavy oil recovery.
TL;DR: In this article , a seismic-geological integrated method that is based on main controlling factors to predict coalbed gas content was proposed, and a weighted fusion method was proposed to construct a multivariate linear model to quantitatively predict the gas content.
TL;DR: In this article , an anionic three-dimensional framework with column-layered structure was synthesized, where octahedral cages are connected by O atoms to form 1D columnar SBUs, and every four SBUs is connected by L2- to form a square channel 3D framework.
Abstract: An anionic three-dimensional framework {(Me2NH2)2[Zn8(L)6(ad)4(μ4-O)]·10DMF·11H2O}(Zn-MOF, L2- = 4,4'-(3-aminopyridine-2,5-diyl)dibenzoic acid; ad- = adeninate) with a column-layered structure was synthesized. Structural studies show that the Zn-MOF has octahedral cages [Zn8(ad)4(μ4-O)], the adjacent cages are connected by O atoms to form 1D columnar SBUs, and every four SBUs are connected by L2- to form a square channel 3D framework. Gas adsorption studies show that the BET and Langmuir surface areas of Zn-MOF are 1370.31 and 1478.04 m2 g-1, respectively, and the total pore volume for single-point adsorption is 0.528 cm3 g-1. The surface of the pores of the Zn-MOF is occupied by open metal sites and uncoordinated carboxyl groups, showing good capture ability for C2H2 and good adsorption selectivity for C2H2/CH4. More importantly, the free (CH3)2NH2+ ions present in the pores of the columnar layered Zn-MOF can cation-exchange with MB, MV, and RhB ions in aqueous solution. Therefore, Zn-MOF can not only effectively adsorb the cationic dyes MB, MV, and RhB, but also exhibit particularly selective sorption towards the mixed anion and cation dyes MB/MO and MV/MO. In addition, a series of fluorescence experiments show that Zn-MOF has good fluorescence properties, exhibiting highly selective and sensitive fluorescence detection and recognition performance for Fe3+ ions in aqueous solution with a low detection limit.
TL;DR: In this paper , the performance of phase change random access memory (PCRAM) cells with Cr 0.39Sb2Te (CST) dopant was investigated and the results indicated that the CST material is a potential candidate for universal memory devices.
TL;DR: In this paper , two metal-organic frameworks (MOFs), Ni-Ade-TCPE and Co-Adde-PCPE, were synthesized by employing mixed adenine and tetrakis(4-carboxyphenyl)ethylene (H 4 TCPE), which are 3D microporous structures with 1D open channels decorated by NH 2 sites.
06 Dec 2022
TL;DR: In this article , the photothermal conversion efficiency of Pt/Te nano-heterostructures was achieved by a simple hydrothermal reaction, which achieved an accuracy of 51.84%.
Abstract: Photothermal therapy is a powerful candidate for tumor treatment. However, photothermal therapy still faces some challenges, such as lacking photothermal agents with high photothermal conversion efficiency and undesirable inflammatory responses, which may result in tumor recurrence and therapeutic resistance. Here, the Pt/Te nanoheterostructures (PT) were synthesized by a simple hydrothermal reaction. The photothermal conversion efficiency was up to 51.84%. The outstanding photothermal conversion capacity of PT was attributed to the unique localized surface plasmon resonance frequency of metals and semiconductors and the increased circuit paths of electron transitions from nanoheterostructures. After coating with the murine mammary carcinoma (4T1) cell membrane, the camouflaged PT (mPT) exhibits excellent biocompatibility and effective homologous targeting capacity. Benefiting from antioxidative activity, mPT can efficiently scavenge inflammation-related reactive oxygen species and cytokines (such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6) caused by hyperthermia to alleviate inflammation in vitro and in vivo. The in vitro and in vivo therapeutic results showed that mPT could effectively inhibit 4T1 breast tumors. In addition, the in vivo therapy could be guided by photoacoustic imaging. These results demonstrated that these multifunctional mPT provide a paradigm for biomimetic metal and semiconductor nanoheterostructures for enhanced photothermal therapy and anti-inflammatory action on tumors.
TL;DR: In this paper , a hybrid inorganic-organic ionic semiconductor (Ni(Phen)3][V14O34Cl]Cl (Phen = 1,10-phenanthroline) was observed to have photovoltaic effect in ionic liquid solution.
Abstract: Semiconductor materials were adopted in their solid states for photovoltaic applications owing to their nonsolubility and/or breaking of the photogenerated carrier transfer pathway in solution. The liquid-state photovoltaic device fills in a gap between currently prevailing full-solid-state and solid-liquid-state solar cells; however, reports on the photovoltaic effect from realistic semiconductor solution are absent so far. Herein, we report a hybrid inorganic-organic ionic semiconductor [Ni(Phen)3][V14O34Cl]Cl (Phen = 1,10-phenanthroline) and observe its photovoltaic effect in ionic liquid solution. This photovoltaic effect arises as a result of charge transfer between the coordination cation and inorganic polyoxovanadate in solution under illumination and subsequent transfer to electrodes. The liquid-state photovoltaic device (cell configuration: carbon cloth||[Ni(Phen)3][V14O34Cl]Cl in ionic liquid||Al foam) yields an open-circuit voltage of ca. 1.199 V and a photocurrent density of 3.268 mA cm-2 upon illumination using an air mass of 1.5 (100 mW cm-2) at 80 °C with a fill factor of 42.48% and an efficiency of 1.665%. This novel type of hybrid ionic semiconductor possesses great structural tunability for an optimized photovoltaic performance.