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Barbara Ingold Heppner
Researcher at Charité
Publications - 13
Citations - 1791
Barbara Ingold Heppner is an academic researcher from Charité. The author has contributed to research in topics: Breast cancer & Neoadjuvant therapy. The author has an hindex of 7, co-authored 13 publications receiving 1103 citations. Previous affiliations of Barbara Ingold Heppner include Humboldt University of Berlin.
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Journal ArticleDOI
Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy
Carsten Denkert,Gunter von Minckwitz,Silvia Darb-Esfahani,Bianca Lederer,Barbara Ingold Heppner,Karsten Weber,Jan Budczies,Jens Huober,Frederick Klauschen,Jenny Furlanetto,Wolfgang D. Schmitt,Jens-Uwe Blohmer,Thomas Karn,Berit M. Pfitzner,Sherko Kümmel,Knut Engels,Andreas Schneeweiss,Arndt Hartmann,Aurelia Noske,Peter A. Fasching,Christian Jackisch,Marion van Mackelenbergh,Peter Sinn,Christian Schem,Claus Hanusch,Michael Untch,Sibylle Loibl +26 more
TL;DR: The hypothesis that breast cancer is immunogenic and might be targetable by immune-modulating therapies is supported and increased TIL concentration predicted response to neoadjuvant chemotherapy in all molecular subtypes assessed.
Journal ArticleDOI
Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group.
Carsten Denkert,Stephan Wienert,Audrey Poterie,Sibylle Loibl,Jan Budczies,Sunil V. Badve,Zsuzsanna Bago-Horvath,Anita Bane,Shahinaz Bedri,Jane E. Brock,Ewa Chmielik,Matthias Christgen,Cecile Colpaert,Sandra Demaria,Gert Van den Eynden,Giuseppe Floris,Stephen B. Fox,Dongxia Gao,Barbara Ingold Heppner,S Rim Kim,Zuzana Kos,Hans Kreipe,Sunil R. Lakhani,Frédérique Penault-Llorca,Giancarlo Pruneri,Nina Radosevic-Robin,David L. Rimm,Stuart J. Schnitt,Bruno Valentin Sinn,Bruno Valentin Sinn,Peter Sinn,Nicolas Sirtaine,Sandra A O'Toole,Giuseppe Viale,Koen Van de Vijver,Roland de Wind,Gunter von Minckwitz,Frederick Klauschen,Michael Untch,Peter A. Fasching,Toralf Reimer,Karen Willard-Gallo,Stefan Michiels,Sherene Loi,Roberto Salgado +44 more
TL;DR: This large international standardization project shows that reproducible evaluation of TIL is feasible in breast cancer and opens the way for standardized reporting of tumor immunological parameters in clinical studies and diagnostic practice.
Journal ArticleDOI
Tumor-Infiltrating Lymphocytes: A Predictive and Prognostic Biomarker in Neoadjuvant-Treated HER2-Positive Breast Cancer
Barbara Ingold Heppner,Michael Untch,Carsten Denkert,Berit M. Pfitzner,Bianca Lederer,Wolfgang D. Schmitt,Holger Eidtmann,Peter A. Fasching,Hans Tesch,Christine Solbach,Mahdi Rezai,Dirk Michael Zahm,Frank Holms,Manfred Glados,Petra Krabisch,Esther Heck,Angelika Ober,Petra Lorenz,Kurt Diebold,Jörg-Olaf Habeck,Sibylle Loibl +20 more
TL;DR: In combination with pCR rate, TILs may help to stratify prognostic subgroups, thereby guiding future therapy decisions and demonstrating the predictive and prognostic impact of Tils in HER2-positive breast cancer in the neoadjuvant setting.
Posted ContentDOI
Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients
Jenny Meinhardt,Josefine Radke,Carsten Dittmayer,Ronja Mothes,Jonas Franz,Michael Laue,Julia Schneider,Sebastian Brünink,Olga Hassan,Werner Stenzel,Marc Windgassen,Larissa Rößler,Hans-Hilmar Goebel,Hubert Martin,Andreas Nitsche,Walter J. Schulz-Schaeffer,Samy Hakroush,Martin Sebastian Winkler,Björn Tampe,Sefer Elezkurtaj,David Horst,Lars Oesterhelweg,Michael Tsokos,Barbara Ingold Heppner,Christine Stadelmann,Christian Drosten,Victor M. Corman,Helena Radbruch,Frank L. Heppner +28 more
TL;DR: By precisely investigating and anatomically mapping oro- and pharyngeal regions and brains of 32 patients dying from COVID-19, CNS infarction due to cerebral thromboembolism is described, and SARS-CoV-2 neurotropism is demonstrated.