J
Josefine Radke
Researcher at Humboldt University of Berlin
Publications - 55
Citations - 2406
Josefine Radke is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 45 publications receiving 1180 citations. Previous affiliations of Josefine Radke include University of Zurich & German Cancer Research Center.
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Journal ArticleDOI
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Jenny Meinhardt,Josefine Radke,Carsten Dittmayer,Jonas Franz,Jonas Franz,Carolina Thomas,Carolina Thomas,Ronja Mothes,Michael Laue,Julia Schneider,Sebastian Brünink,Selina Greuel,Malte Lehmann,Olga Hassan,Tom Aschman,Elisa Schumann,Robert Lorenz Chua,Christian Conrad,Roland Eils,Roland Eils,Werner Stenzel,Marc Windgassen,Larissa Rößler,Hans-Hilmar Goebel,Hans R. Gelderblom,Hubert Martin,Andreas Nitsche,Walter J. Schulz-Schaeffer,Samy Hakroush,Martin Sebastian Winkler,Björn Tampe,Franziska Scheibe,Peter Körtvelyessy,Peter Körtvelyessy,Dirk Reinhold,Britta Siegmund,Anja A. Kühl,Sefer Elezkurtaj,David Horst,Lars Oesterhelweg,Michael Tsokos,Barbara Ingold-Heppner,Christine Stadelmann,Christian Drosten,Victor M. Corman,Helena Radbruch,Frank L. Heppner +46 more
TL;DR: The morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and evidence of SARS-CoV-2 neurotropism are described and presented.
Journal ArticleDOI
P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases.
TL;DR: The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan, and might help to discriminate activated microglial and infiltrating myeloid cells from quiescent microglian cells in the human CNS.
Journal ArticleDOI
Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke
Francisco Fernández-Klett,Jason R. Potas,Jason R. Potas,Diana Hilpert,Katja Blazej,Josefine Radke,Jojanneke H J Huck,Odilo Engel,Werner Stenzel,Guillem Genové,Josef Priller +10 more
TL;DR: It is suggested that a previously unrecognized population of CNS-resident stromal cells drives a dynamic process of scarring after cerebral ischemia, which appears distinct from the glial scar and represents a novel target for regenerative stroke therapies.
Posted ContentDOI
Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients
Jenny Meinhardt,Josefine Radke,Carsten Dittmayer,Ronja Mothes,Jonas Franz,Michael Laue,Julia Schneider,Sebastian Brünink,Olga Hassan,Werner Stenzel,Marc Windgassen,Larissa Rößler,Hans-Hilmar Goebel,Hubert Martin,Andreas Nitsche,Walter J. Schulz-Schaeffer,Samy Hakroush,Martin Sebastian Winkler,Björn Tampe,Sefer Elezkurtaj,David Horst,Lars Oesterhelweg,Michael Tsokos,Barbara Ingold Heppner,Christine Stadelmann,Christian Drosten,Victor M. Corman,Helena Radbruch,Frank L. Heppner +28 more
TL;DR: By precisely investigating and anatomically mapping oro- and pharyngeal regions and brains of 32 patients dying from COVID-19, CNS infarction due to cerebral thromboembolism is described, and SARS-CoV-2 neurotropism is demonstrated.
Journal ArticleDOI
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Mario Witkowski,Mario Witkowski,Caroline Tizian,Marta Ferreira-Gomes,Daniela Niemeyer,Daniela Niemeyer,Terry Jones,Terry Jones,Terry Jones,Frederik Heinrich,Stefan Frischbutter,Stefan Angermair,Thordis Hohnstein,Irene Mattiola,Philipp Nawrath,Sophie Mc Ewen,Silvia Zocche,Edoardo Viviano,Gitta Anne Heinz,Marcus Maurer,Uwe Kölsch,Robert Lorenz Chua,Tom Aschman,Christian Meisel,Josefine Radke,Birgit Sawitzki,Jobst Roehmel,Kristina Allers,V. Moos,Thomas Schneider,Leif G. Hanitsch,Marcus A. Mall,Christian Conrad,Helena Radbruch,Claudia U. Duerr,Joseph A. Trapani,Emanuela Marcenaro,Tilmann Kallinich,Victor M. Corman,Victor M. Corman,Florian Kurth,Leif E. Sander,Christian Drosten,Christian Drosten,Sascha Treskatsch,Pawel Durek,Andrey Kruglov,Andrey Kruglov,Andreas Radbruch,Mir-Farzin Mashreghi,Andreas Diefenbach,Andreas Diefenbach +51 more
TL;DR: In this article, the authors show that in severe SARS-CoV-2, natural killer (NK) cells show remarkable defects in virus control, cytokine production and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules.