Marion van Mackelenbergh

TL;DR: The hypothesis that breast cancer is immunogenic and might be targetable by immune-modulating therapies is supported and increased TIL concentration predicted response to neoadjuvant chemotherapy in all molecular subtypes assessed.

TL;DR: The findings show a network of deregulated exosomal miRNAs with specific expression patterns in exosomes of HER2-positive and TNBC patients that are also associated with clinicopathological parameters and pCR within each BC subtype.

TL;DR: The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes, and the need for gene‐specific calibration of evidence types used for variant classification is justified.

TL;DR: Improvements in strength, endurance and QoL from exercise training are highlighted and support its implementation in standard of care during chemotherapy for patients with breast cancer.

TL;DR: Increased immunological anti-cancer activity due to physical activity is probably mediated via an increase in number and cytotoxicity of monocytes and natural killer cells and cytokines.