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Branko Cirovic
Researcher at University of Bonn
Publications - 14
Citations - 586
Branko Cirovic is an academic researcher from University of Bonn. The author has contributed to research in topics: Immunity & Biology. The author has an hindex of 6, co-authored 10 publications receiving 272 citations.
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Journal ArticleDOI
BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
Branko Cirovic,L. Charlotte J. de Bree,L. Charlotte J. de Bree,L. Charlotte J. de Bree,Laszlo Groh,Bas A. Blok,Bas A. Blok,Bas A. Blok,Joyce Chan,Walter J.F.M. van der Velden,Manita E J Bremmers,Reinout van Crevel,Kristian Händler,Simone Picelli,Jonas Schulte-Schrepping,Kathrin Klee,Marije Oosting,Valerie A. C. M. Koeken,Jakko van Ingen,Yang Li,Yang Li,Christine Stabell Benn,Christine Stabell Benn,Joachim L. Schultze,Joachim L. Schultze,Leo A. B. Joosten,Nigel Curtis,Mihai G. Netea,Mihai G. Netea,Andreas Schlitzer,Andreas Schlitzer +30 more
TL;DR: It is shown that BCG vaccination in healthy human volunteers induces a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell (HSPC) compartment in the bone marrow.
Journal ArticleDOI
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2
Jil Sander,Susanne V. Schmidt,Branko Cirovic,Naomi McGovern,Naomi McGovern,Olympia Papantonopoulou,Anna-Lena Hardt,Anna C. Aschenbrenner,Christoph Kreer,Thomas Quast,Alexander M. Xu,Lisa Schmidleithner,Heidi Theis,Lan Do Thi Huong,Hermi Sumatoh,Mario A. Lauterbach,Jonas Schulte-Schrepping,Patrick Günther,Jia Xue,Kevin Baßler,Thomas Ulas,Kathrin Klee,Natalie Katzmarski,Stefanie Herresthal,Wolfgang Krebs,Bianca Martin,Eicke Latz,Eicke Latz,Eicke Latz,Kristian Händler,Michael Kraut,Waldemar Kolanus,Marc Beyer,Marc Beyer,Christine S. Falk,Bettina Wiegmann,Sven Burgdorf,Nicholas A. Melosh,Evan W. Newell,Florent Ginhoux,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze +43 more
TL;DR: Monocyte‐derived dendritic cells are transcriptionally relate to in vivo inflammatory monocytes, that they integrate differentiation cues time dependently, and that in vitro differentiated monocytes are phenotypically heterogeneous.
Journal ArticleDOI
β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32.
Jéssica Cristina dos Santos,Jéssica Cristina dos Santos,Ana Marina Barroso de Figueiredo,Muriel Vilela Teodoro Silva,Branko Cirovic,L. Charlotte J. de Bree,L. Charlotte J. de Bree,L. Charlotte J. de Bree,Michelle S M A Damen,Michelle S M A Damen,Simone J.C.F.M. Moorlag,Rodrigo Saar Gomes,Monique M. Helsen,Marije Oosting,Samuel T. Keating,Andreas Schlitzer,Andreas Schlitzer,Mihai G. Netea,Mihai G. Netea,Fátima Ribeiro-Dias,Leo A. B. Joosten,Leo A. B. Joosten +21 more
TL;DR: It is demonstrated that monocytes trained with the fungal cell wall component β-glucan confer enhanced protection against infections caused by Leishmania braziliensis through the enhanced production of proinflammatory cytokines.
Journal ArticleDOI
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner.
Valerie A. C. M. Koeken,L. Charlotte J. de Bree,Vera P. Mourits,Simone J.C.F.M. Moorlag,Jona Walk,Branko Cirovic,Rob J.W. Arts,Martin Jaeger,Helga Dijkstra,Heidi Lemmers,Leo A. B. Joosten,Christine Stabell Benn,Reinout van Crevel,Mihai G. Netea,Mihai G. Netea +14 more
TL;DR: The capacity of BCG to enhance microbial responsiveness while dampening systemic inflammation should be further explored for potential therapeutic applications.
Journal ArticleDOI
Transmission of trained immunity and heterologous resistance to infections across generations.
Natalie Katzmarski,Jorge Domínguez-Andrés,Jorge Domínguez-Andrés,Branko Cirovic,Georgios Renieris,Eleonora Ciarlo,Didier Le Roy,Konstantin Lepikhov,Kathrin Kattler,Gilles Gasparoni,Kristian Händler,Heidi Theis,Marc Beyer,Jos W. M. van der Meer,Leo A. B. Joosten,Leo A. B. Joosten,Jörn Walter,Joachim L. Schultze,Joachim L. Schultze,Thierry Roger,Evangelos J. Giamarellos-Bourboulis,Andreas Schlitzer,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea +24 more
TL;DR: In this article, the authors provide evidence for transmission of trained immunity across generations to murine progeny that survived a sub-lethal systemic infection with Candida albicans or a zymosan challenge.