J
Jona Walk
Researcher at Radboud University Nijmegen
Publications - 22
Citations - 549
Jona Walk is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 10, co-authored 15 publications receiving 326 citations.
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Journal ArticleDOI
Outcomes of controlled human malaria infection after BCG vaccination.
Jona Walk,L. Charlotte J. de Bree,Wouter Graumans,Rianne Stoter,Geert-Jan van Gemert,Marga van de Vegte-Bolmer,Karina Teelen,Cornelus C. Hermsen,Rob J.W. Arts,Marije C. Behet,Farid Keramati,Simone J.C.F.M. Moorlag,Annie S. P. Yang,Reinout van Crevel,Peter Aaby,Quirijn de Mast,André J. A. M. van der Ven,Christine Stabell Benn,Christine Stabell Benn,Mihai G. Netea,Mihai G. Netea,Robert W. Sauerwein +21 more
TL;DR: It is shown that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.
Journal ArticleDOI
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner.
Valerie A. C. M. Koeken,L. Charlotte J. de Bree,Vera P. Mourits,Simone J.C.F.M. Moorlag,Jona Walk,Branko Cirovic,Rob J.W. Arts,Martin Jaeger,Helga Dijkstra,Heidi Lemmers,Leo A. B. Joosten,Christine Stabell Benn,Reinout van Crevel,Mihai G. Netea,Mihai G. Netea +14 more
TL;DR: The capacity of BCG to enhance microbial responsiveness while dampening systemic inflammation should be further explored for potential therapeutic applications.
Journal ArticleDOI
Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial.
Jona Walk,Isaie J. Reuling,Marije C. Behet,Lisette Meerstein-Kessel,Wouter Graumans,Geert-Jan van Gemert,Rianne Siebelink-Stoter,Marga van de Vegte-Bolmer,Thorsten Janssen,Karina Teelen,Johannes H. W. de Wilt,Quirijn de Mast,André J. A. M. van der Ven,Ernest Diez Benavente,Susana Campino,Taane G. Clark,Martijn A. Huynen,Cornelus C. Hermsen,Else M. Bijker,Anja Scholzen,Robert W. Sauerwein +20 more
TL;DR: Although highly protective against homologous parasites, NF54-CPS-induced immunity is less effective against heterologous parasite clones both in vivo and in vitro, indicating that whole sporozoite-based vaccine approaches require more potent immune responses forheterologous protection.
Journal ArticleDOI
A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1.
Meta Roestenberg,Jona Walk,Saskia C. van der Boor,Marijke C. C. Langenberg,Marie-Astrid Hoogerwerf,Jacqueline J. Janse,Mikhael D Manurung,X. Zen Yap,Amanda Fabra García,Jan Pieter R. Koopman,Pauline Meij,Els Wessels,Karina Teelen,Youri M van Waardenburg,Marga van de Vegte-Bolmer,Geert-Jan van Gemert,Leo G. Visser,André J. A. M. van der Ven,Quirijn de Mast,Natasha Kc,Yonas Abebe,Tooba Murshedkar,Peter F. Billingsley,Tom L. Richie,B. Kim Lee Sim,Chris J. Janse,Stephen L. Hoffman,Shahid M. Khan,Robert W. Sauerwein +28 more
TL;DR: Although no definite conclusion can be drawn on the potential strength of protective efficacy of PfSPz-GA1 Vaccine, the favorable safety profile and induced immune responses by PfSPZ-GA2 Vaccine warrant further clinical evaluation.
Journal ArticleDOI
Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers.
Matthew B. B. McCall,Linda J. Wammes,Marijke C. C. Langenberg,Geert-Jan van Gemert,Jona Walk,Cornelus C. Hermsen,Wouter Graumans,Rob Koelewijn,Jean-François Franetich,Sandra Chishimba,Max Gerdsen,Audrey Lorthiois,Marga van de Vegte,Dominique Mazier,Else M. Bijker,Jaap J. van Hellemond,Perry J.J. van Genderen,Robert W. Sauerwein +17 more
TL;DR: It is shown that sporozoites of diverse geographic and genetic origin differ in their capacity to infect and develop within human liver cells in culture, which matched their ability to form blood-stage parasites in human volunteers undergoing a controlled malaria infection.