F
Faisal I. Rezwan
Researcher at Cranfield University
Publications - 71
Citations - 2525
Faisal I. Rezwan is an academic researcher from Cranfield University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 20, co-authored 63 publications receiving 1662 citations. Previous affiliations of Faisal I. Rezwan include Southampton General Hospital & Aberystwyth University.
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Journal ArticleDOI
ArrayExpress update—from an archive of functional genomics experiments to the atlas of gene expression
Helen Parkinson,Misha Kapushesky,Nikolay Kolesnikov,Gabriella Rustici,Mohammadreza Shojatalab,Niran Abeygunawardena,Hugo Bérubé,Miroslaw Dylag,Ibrahim Emam,Anna Farne,Ele Holloway,Margus Lukk,James Malone,Roby Mani,Ekaterina Pilicheva,Tim F. Rayner,Faisal I. Rezwan,Anjan Sharma,Eleanor Williams,Xiangqun Zheng Bradley,Tomasz Adamusiak,Marco Brandizi,Tony Burdett,Richard M.R. Coulson,Maria Krestyaninova,Pavel Kurnosov,Eamonn Maguire,Sudeshna Guha Neogi,Philippe Rocca-Serra,Susanna-Assunta Sansone,Nataliya Sklyar,Mengyao Zhao,Ugis Sarkans,Alvis Brazma +33 more
TL;DR: This update describes the ArrayExpress developments over the last two years and describes the new summary database and meta-analytical tool of ranked gene expression across multiple experiments and different biological conditions.
Journal ArticleDOI
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Gemma C Sharp,Gemma C Sharp,Lucas A. Salas,Lucas A. Salas,Claire Monnereau,Claire Monnereau,Catherine Allard,Paul Yousefi,Todd M. Everson,Jon Bohlin,Zongli Xu,Rae-Chi Huang,Sarah E. Reese,Cheng-Jian Xu,Nour Baïz,Cathrine Hoyo,Golareh Agha,Ritu Roy,Ritu Roy,John W. Holloway,Akram Ghantous,Simon Kebede Merid,Kelly M. Bakulski,Leanne K. Küpers,Hongmei Zhang,Rebecca C Richmond,Christian M. Page,Liesbeth Duijts,Liesbeth Duijts,Rolv T. Lie,Phillip E. Melton,Judith M. Vonk,Ellen A. Nohr,ClarLynda R. Williams-DeVane,Karen Huen,Sheryl L. Rifas-Shiman,Carlos Ruiz-Arenas,Semira Gonseth,Semira Gonseth,Faisal I. Rezwan,Zdenko Herceg,Sandra Ekström,Lisa A. Croen,Fahimeh Falahi,Patrice Perron,Margaret R. Karagas,Bilal M. Quraishi,Matthew Suderman,Maria C. Magnus,Maria C. Magnus,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe,Jack A. Taylor,Jack A. Taylor,Denise Anderson,Shanshan Zhao,Henriette A. Smit,Michele J. Josey,Michele J. Josey,Asa Bradman,Andrea A. Baccarelli,Mariona Bustamante,Siri E. Håberg,Göran Pershagen,Göran Pershagen,Irva Hertz-Picciotto,Craig J. Newschaffer,Eva Corpeleijn,Luigi Bouchard,Debbie A Lawlor,Rachel L. Maguire,Lisa F. Barcellos,George Davey Smith,Brenda Eskenazi,Wilfried Karmaus,Carmen J. Marsit,Marie-France Hivert,Marie-France Hivert,Harold Snieder,M. Daniele Fallin,Erik Melén,Erik Melén,Erik Melén,Monica Cheng Munthe-Kaas,Monica Cheng Munthe-Kaas,S. Hasan Arshad,S. Hasan Arshad,Joseph L. Wiemels,Isabella Annesi-Maesano,Martine Vrijheid,Emily Oken,Nina Holland,Susan K. Murphy,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Gerard H. Koppelman,John P. Newnham,Allen J. Wilcox,Wenche Nystad,Stephanie J. London,Janine F. Felix,Janine F. Felix,Caroline L Relton +103 more
TL;DR: In this article, the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs).
Journal ArticleDOI
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans
Louise E. Docherty,Louise E. Docherty,Faisal I. Rezwan,Faisal I. Rezwan,Rebecca L. Poole,Rebecca L. Poole,Claire L. S. Turner,Emma Kivuva,Eamonn R. Maher,Sarah F. Smithson,Julian P Hamilton-Shield,Michal Patalan,Maria Gizewska,Jarosław Peregud-Pogorzelski,Jasmin Beygo,Karin Buiting,Bernhard Horsthemke,Lukas Soellner,Matthias Begemann,Thomas Eggermann,Emma L. Baple,Sahar Mansour,I. Karen Temple,I. Karen Temple,Deborah J G Mackay,Deborah J G Mackay +25 more
TL;DR: NLRP5 mutations suggest connections between maternal reproductive fitness, early zygotic development and genomic imprinting, and are reported in five mothers of individuals affected by multilocus imprinting disturbance.
Journal ArticleDOI
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Sarah E. Reese,Cheng-Jian Xu,Herman T. den Dekker,Mi Kyeong Lee,Sinjini Sikdar,Carlos Ruiz-Arenas,Simon Kebede Merid,Faisal I. Rezwan,Christian M. Page,Christian M. Page,Vilhelmina Ullemar,Phillip E. Melton,Phillip E. Melton,Sam S. Oh,Ivana V. Yang,Kimberley Burrows,Cilla Söderhäll,Dereje D. Jima,Lu Gao,Ryan Arathimos,Leanne K. Küpers,Leanne K. Küpers,Matthias Wielscher,Peter Rzehak,Jari Lahti,Catherine Laprise,Anne-Marie Madore,James M. Ward,Brian D. Bennett,Tianyuan Wang,Douglas A. Bell,Judith M. Vonk,Siri E. Håberg,Shanshan Zhao,Robert Karlsson,Elysia M. Hollams,Donglei Hu,Adam J. Richards,Anna Bergström,Anna Bergström,Gemma C Sharp,Janine F. Felix,Mariona Bustamante,Olena Gruzieva,Olena Gruzieva,Rachel L. Maguire,Rachel L. Maguire,Frank D. Gilliland,Nour Baïz,Ellen A. Nohr,Eva Corpeleijn,Sylvain Sebert,Sylvain Sebert,Wilfried Karmaus,Veit Grote,Eero Kajantie,Eero Kajantie,Eero Kajantie,Maria C. Magnus,Maria C. Magnus,Anne K. Örtqvist,Celeste Eng,Andrew H. Liu,Inger Kull,Inger Kull,Vincent W. V. Jaddoe,Jordi Sunyer,Juha Kere,Juha Kere,Cathrine Hoyo,Isabella Annesi-Maesano,Syed Hasan Arshad,Berthold Koletzko,Bert Brunekreef,Elisabeth B. Binder,Elisabeth B. Binder,Katri Räikkönen,Eva Reischl,John W. Holloway,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Harold Snieder,Nabila Kazmi,Carrie V. Breton,Susan K. Murphy,Göran Pershagen,Göran Pershagen,Josep M. Antó,Caroline L Relton,David A. Schwartz,Esteban G. Burchard,Rae-Chi Huang,Wenche Nystad,Catarina Almqvist,Catarina Almqvist,A. John Henderson,Erik Melén,Erik Melén,Liesbeth Duijts,Gerard H. Koppelman,Stephanie J. London +100 more
TL;DR: This article identified differential DNA methylation profiles in newborns and children related to childhood asthma, and identified differentially methylated regions in the newborns' DNA and children's DNA methylations.
Posted ContentDOI
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Josine L. Min,Gibran Hemani,Eilis Hannon,Koen F. Dekkers,Juan E. Castillo-Fernandez,René Luijk,Elena Carnero-Montoro,Elena Carnero-Montoro,Daniel Lawson,Kimberley Burrows,Matthew Suderman,Andrew D. Bretherick,Tom G. Richardson,Johanna Klughammer,Valentina Iotchkova,Gemma C Sharp,Ahmad Al Khleifat,Aleksey Shatunov,Alfredo Iacoangeli,Wendy L. McArdle,Karen M Ho,Ashok Kumar,Ashok Kumar,Ashok Kumar,Cilla Söderhäll,Carolina Soriano-Tárraga,Eva Giralt-Steinhauer,Nabila Kazmi,Dan Mason,Allan F. McRae,David L. Corcoran,Karen Sugden,Silva Kasela,Alexia Cardona,Felix R. Day,Giovanni Cugliari,Clara Viberti,Simonetta Guarrera,Michael Lerro,Richa Gupta,Sailalitha Bollepalli,Pooja R. Mandaviya,Yanni Zeng,Yanni Zeng,Toni-Kim Clarke,Rosie M. Walker,Rosie M. Walker,Vanessa Schmoll,Darina Czamara,Carlos Ruiz-Arenas,Faisal I. Rezwan,Riccardo E. Marioni,Tian Lin,Yvonne Awaloff,Marine Germain,Dylan Aïssi,Ramona A. J. Zwamborn,Kristel R. van Eijk,Annelot M. Dekker,Jenny van Dongen,Jouke-Jan Hottenga,Gonneke Willemsen,Cheng-Jian Xu,Guillermo Barturen,Francesc Català-Moll,Martin Kerick,Carol A. Wang,Phillip E. Melton,Hannah R Elliott,Jean Shin,Manon Bernard,Idil Yet,Melissa C. Smart,T.J. Gorrie-Stone,Christopher Shaw,Ammar Al Chalabi,Ammar Al Chalabi,Susan M. Ring,Göran Pershagen,Erik Melén,Jordi Jimenez-Conde,Jaume Roquer,Debbie A Lawlor,John Wright,Nicholas G. Martin,Grant W. Montgomery,Terrie E. Moffitt,Richie Poulton,Tõnu Esko,Tõnu Esko,Lili Milani,Andres Metspalu,John R. B. Perry,Ken K. Ong,Nicholas J. Wareham,Giuseppe Matullo,Carlotta Sacerdote,Avshalom Caspi,Louise Arseneault,Miina Ollikainen,Jaakko Kaprio,Janine F. Felix,Fernando Rivadeneira,Henning Tiemeier,Henning Tiemeier,Marinus H. van IJzendoorn,Marinus H. van IJzendoorn,André G. Uitterlinden,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe,Chris Haley,Andrew M. McIntosh,Andrew M. McIntosh,Kathryn L. Evans,Kathryn L. Evans,Alison D. Murray,Katri Räikkönen,Jari Lahti,Ellen A. Nohr,Ellen A. Nohr,Thorkild I. A. Sørensen,Torben Hansen,Camilla Schmidt Morgen,Elisabeth B. Binder,Elisabeth B. Binder,Susanne Lucae,Juan R. González,Mariona Bustamante,Jordi Sunyer,John W. Holloway,Wilfried Karmaus,Hongmei Zhang,Ian J. Deary,Naomi R. Wray,John M. Starr,Marian Beekman,Diana van Heemst,P. Eline Slagboom,Pierre-Emmanuel Morange,David-Alexandre Trégouët,Jan H. Veldink,Gareth E. Davies,Eco J. C. de Geus,Dorret I. Boomsma,Judith M. Vonk,Bert Brunekreef,Gerard H. Koppelman,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Rae-Chi Huang,Craig E. Pennell,Joyce B. J. van Meurs,M. Arfan Ikram,Alun D. Hughes,Therese Tillin,Nish Chaturvedi,Zdenka Pausova,Tomáš Paus,Tim D. Spector,Meena Kumari,Leonard C. Schalkwyk,Peter M. Visscher,George Davey Smith,Christoph Bock,Tom R. Gaunt,Jordana T. Bell,Bastiaan T. Heijmans,Jonathan Mill,Caroline L Relton +168 more
TL;DR: Results of DNA methylation-quantitative trait loci (mQTL) analyses on 32,851 participants reveal that the genetic architecture of DNAm levels is highly polygenic and DNAm exhibits signatures of negative and positive natural selection.