Carrie Sims

TL;DR: Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages, and help define key evolutionary events within vertebrate lineages.

TL;DR: Genetic evidence for interplay between Lrp4 and Wise in inhibiting Wnt/β-catenin signaling is presented and an insight is provided into how modulation of Wnt / β-catanin signaling controls cellular processes important for skin placode formation.

TL;DR: It is found that a Hoxa2 cis-regulatory module consists of five elements that direct expression in r2 of the developing hindbrain, and provides important insight into the regulation of segmental identity in the anterior hindbrain.

TL;DR: Lrp4 can act as both inhibitor and activator of the Wnt/β-catenin pathway through interactions with Wise to determine tooth number and patterning in mouse, and the data suggest a model whereby Lrp 4 modulates Wnt-related signaling via interaction with Wnt ligands and antagonists in a context-dependent manner.

TL;DR: During chordate evolution, cis-elements dependent upon Hox/Pbx regulatory complexes, are responsible for key aspects of segmental Hox expression in neural tissue and appeared with urochordates after cephalochordate divergence.