Catherine A. Meldrum

TL;DR: Airway epithelial cells from patients with COPD show higher baseline levels of cytokine expression and increased susceptibility to RV infection, despite an increased IFN response.

TL;DR: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD and airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphySEma.

TL;DR: This cross-sectional study implies that COPD progression is associated with significant increases in costimulatory molecule expression by multiple lung DC subsets, and interactions with lung DCs may contribute to the immunophenotype of CD4(+) T cells in advanced COPD.

TL;DR: CAPTURE with PEF can identify patients with COPD who would benefit from currently available therapy and require further diagnostic evaluation, and improved SN and specificity for all cases versus all control subjects.

TL;DR: Analysis of clinically indicated lung resections from three human cohorts suggests that the production of proinflammatory cytokines and cytotoxic molecules by lung-resident CD8+ T cells contributes to COPD pathogenesis.