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Chad V. Pecot
Researcher at University of North Carolina at Chapel Hill
Publications - 89
Citations - 5992
Chad V. Pecot is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 34, co-authored 78 publications receiving 4897 citations. Previous affiliations of Chad V. Pecot include University of Texas Health Science Center at Houston & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
RNA interference in the clinic: challenges and future directions
TL;DR: Current challenges to the development of synthetic RNAi-based therapies are explored and new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release are considered.
Journal ArticleDOI
Paraneoplastic Thrombocytosis in Ovarian Cancer
Rebecca L. Stone,Alpa M. Nick,Iain A. McNeish,Frances R. Balkwill,Hee Dong Han,Justin Bottsford-Miller,Rajesha Rupaimoole,Guillermo N. Armaiz-Pena,Chad V. Pecot,Jermaine Coward,Michael T. Deavers,Hernan G. Vasquez,Diana L. Urbauer,Charles N. Landen,Wei Hu,Hannah Gershenson,Koji Matsuo,Mian M.K. Shahzad,Erin R. King,Ibrahim Tekedereli,Bulent Ozpolat,Edward H. Ahn,Virginia K. Bond,Rui Wang,Angela F. Drew,Francisca C. Gushiken,Donald M. Lamkin,Katherine Collins,Koen DeGeest,Susan K. Lutgendorf,Wah Chiu,Gabriel Lopez-Berestein,Vahid Afshar-Kharghan,Anil K. Sood +33 more
TL;DR: Findings support the existence of a paracrine circuit wherein increased production of thrombopoietic cytokines in tumor and host tissue leads to paraneoplasticThrombocytosis, which fuels tumor growth.
Journal ArticleDOI
Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer
Da Yang,Yan Sun,Yan Sun,Limei Hu,Hong Zheng,Hong Zheng,Ping Ji,Chad V. Pecot,Yanrui Zhao,Sheila Reynolds,Hanyin Cheng,Rajesha Rupaimoole,David Cogdell,Matti Nykter,Russell Broaddus,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Jinsong Liu,Ilya Shmulevich,Anil K. Sood,Kexin Chen,Wei Zhang +21 more
TL;DR: Integrated genomic analyses revealed a miRNA-regulatory network that further defined a robust integrated mesenchymal subtype associated with poor overall survival in serous ovarian cancer (OvCa) and predicted eight key miRNAs were predicted to regulate 89% of the targets in this network.
Journal ArticleDOI
Tumour angiogenesis regulation by the miR-200 family
Chad V. Pecot,Rajesha Rupaimoole,Da Yang,Rehan Akbani,Cristina Ivan,Chunhua Lu,Sherry Y. Wu,Hee Dong Han,Maitri Y. Shah,Cristian Rodriguez-Aguayo,Justin Bottsford-Miller,Yuexin Liu,Sang Bae Kim,Anna K. Unruh,Vianey Gonzalez-Villasana,Huang L,Behrouz Zand,Myrthala Moreno-Smith,Lingegowda S. Mangala,Morgan Taylor,Heather J. Dalton,Vasudha Sehgal,Yunfei Wen,Yu Kang,Keith A. Baggerly,Ju Seog Lee,Prahlad T. Ram,Murali Ravoori,Vikas Kundra,Xinna Zhang,Rouba Ali-Fehmi,Ana M. Gonzalez-Angulo,Pierre P. Massion,George A. Calin,Gabriel Lopez-Berestein,Wei Zhang,Anil K. Sood +36 more
TL;DR: A difference in clinical outcome is demonstrated based on miR-200's role in blocking tumour angiogenesis, defined as its utility as a potential therapeutic agent in a cancer-dependent context.
Journal ArticleDOI
Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread
Sunila Pradeep,Seung W. Kim,Sherry Y. Wu,Masato Nishimura,Pradeep Chaluvally-Raghavan,Takahito Miyake,Chad V. Pecot,Sun Jin Kim,Hyun Jin Choi,Farideh Z. Bischoff,J. A. Mayer,Li Huang,Alpa M. Nick,Carolyn S. Hall,Cristian Rodriguez-Aguayo,Behrouz Zand,Heather J. Dalton,Thiruvengadam Arumugam,Ho-Jeong Lee,Hee Dong Han,Hee Dong Han,Min Soon Cho,Rajesha Rupaimoole,Lingegowda S. Mangala,Vasudha Sehgal,Sang Cheul Oh,Sang Cheul Oh,Jinsong Liu,Ju Seog Lee,Robert L. Coleman,Prahlad T. Ram,Gabriel Lopez-Berestein,Isaiah J. Fidler,Anil K. Sood +33 more
TL;DR: A parabiosis model is used that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum and reveals that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogeneous omental metastasis.