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Chaoying Liang
Researcher at University of Texas Southwestern Medical Center
Publications - 16
Citations - 1263
Chaoying Liang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Autoimmunity & Haplotype. The author has an hindex of 9, co-authored 15 publications receiving 1114 citations. Previous affiliations of Chaoying Liang include University of Texas at Dallas & University of Texas at Austin.
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Journal ArticleDOI
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.
Srividya Subramanian,Katalin Tus,Quan Zhen Li,Andrew Wang,Xiang Hong Tian,Jinchun Zhou,Chaoying Liang,Guy Bartov,Lisa D. McDaniel,Xin J. Zhou,Roger A. Schultz,Edward K. Wakeland +11 more
TL;DR: Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7, and FISH analysis demonstrated the translocation of this segment onto the yaa chromosome, suggesting that Sles1 modulates the activation of adaptive immunity in response to innate immune signaling.
Journal ArticleDOI
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study
Christopher J. Lessard,Christopher J. Lessard,Christopher J. Lessard,Indra Adrianto,John A. Ice,Graham B. Wiley,Jennifer A. Kelly,Stuart B. Glenn,Adam Adler,He Li,He Li,Astrid Rasmussen,Adrienne H. Williams,Julie T. Ziegler,Mary E. Comeau,Miranda C. Marion,Benjamin E. Wakeland,Chaoying Liang,Paula S. Ramos,Kiely Grundahl,Caroline J. Gallant,Graciela S. Alarcón,Juan-Manuel Anaya,Sang Cheol Bae,Susan A. Boackle,Elizabeth E. Brown,Deh Ming Chang,Soo-Kyung Cho,Lindsey A. Criswell,Jeffrey C. Edberg,Barry I. Freedman,Gary S. Gilkeson,Chaim O. Jacob,Judith A. James,Judith A. James,Diane L. Kamen,Robert P. Kimberly,Jae Hoon Kim,Javier Martin,Joan T. Merrill,Timothy B. Niewold,So-Yeon Park,Michelle Petri,Bernardo A. Pons-Estel,Rosalind Ramsey-Goldman,John D. Reveille,R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Yeong Wook Song,Anne M. Stevens,Anne M. Stevens,Betty P. Tsao,Luis M. Vilá,Timothy J. Vyse,Chack-Yung Yu,Chack-Yung Yu,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Kenneth M. Kaufman,John B. Harley,John B. Harley,Edward K. Wakeland,Carl D. Langefeld,Patrick M. Gaffney,Patrick M. Gaffney,Courtney G. Montgomery,Kathy L. Moser,Kathy L. Moser +69 more
TL;DR: The results of this study increase the number of confirmed SLE risk loci and identify others warranting further investigation, as well as identifying several genes relevant to immunological pathways showed association with SLE.
Journal ArticleDOI
DGKE Variants Cause a Glomerular Microangiopathy That Mimics Membranoproliferative GN
Fatih Ozaltin,Binghua Li,Alysha Rauhauser,Sung Wan An,Oguz Soylemezoglu,İpek Işık Gönül,Ekim Z. Taskiran,Tulin Ibsirlioglu,Emine Korkmaz,Yelda Bilginer,Ali Duzova,Seza Ozen,Rezan Topaloglu,Nesrin Besbas,Shazia Ashraf,Shazia Ashraf,Yong Du,Chaoying Liang,Phylip Chen,Dongmei Lu,Komal Vadnagara,Susan Arbuckle,Deborah Lewis,Benjamin E. Wakeland,Richard J. Quigg,Richard F. Ransom,Edward K. Wakeland,Matthew K. Topham,Nicolas G. Bazan,Chandra Mohan,Friedhelm Hildebrandt,Friedhelm Hildebrandt,Aysin Bakkaloglu,Chou Long Huang,Massimo Attanasio +34 more
TL;DR: The results not only identify a genetic cause of a glomerular microangiopathy but also suggest that the phosphatidylinositol cycle, which requires DGKE, is critical to the normal function of podocytes.
Journal ArticleDOI
Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity
Prithvi Raj,Ekta Rai,Ekta Rai,Ran Song,Shaheen Khan,Benjamin E. Wakeland,Kasthuribai Viswanathan,Carlos Arana,Chaoying Liang,Bo Zhang,Igor Dozmorov,Ferdicia Carr-Johnson,Mitja Mitrovic,Graham B. Wiley,Jennifer A. Kelly,Bernard Lauwerys,Nancy J. Olsen,Chris Cotsapas,Christine Kim Garcia,Carol Wise,John B. Harley,John B. Harley,Swapan K. Nath,Judith A. James,Chaim O. Jacob,Betty P. Tsao,Chandrashekhar Pasare,David R. Karp,Quan Zhen Li,Patrick M. Gaffney,Edward K. Wakeland +30 more
TL;DR: Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility to systemic lupus erythematosus, demonstrating that common disease alleles contain multiple causal variants modulating multiple immune system genes.
Journal ArticleDOI
Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus
Indra Adrianto,Shaofeng Wang,Graham B. Wiley,Christopher J. Lessard,Jennifer A. Kelly,Adam Adler,Stuart B. Glenn,Adrienne H. Williams,Julie T. Ziegler,Mary E. Comeau,Miranda C. Marion,Benjamin E. Wakeland,Chaoying Liang,Kenneth M. Kaufman,Joel M. Guthridge,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Graciela S. Alarcón,Juan-Manuel Anaya,Sang Cheol Bae,Jae Hoon Kim,Young Bin Joo,Susan A. Boackle,Elizabeth E. Brown,Michelle Petri,Rosalind Ramsey-Goldman,John D. Reveille,Luis M. Vilá,Lindsey A. Criswell,Jeffrey C. Edberg,Barry I. Freedman,Gary S. Gilkeson,Chaim O. Jacob,Judith A. James,Diane L. Kamen,Robert P. Kimberly,Javier Martin,Joan T. Merrill,Timothy B. Niewold,Bernardo A. Pons-Estel,R. Hal Scofield,Anne M. Stevens,Betty P. Tsao,Timothy J. Vyse,Carl D. Langefeld,John B. Harley,Edward K. Wakeland,Kathy L. Moser,Courtney G. Montgomery,Patrick M. Gaffney +49 more
TL;DR: The results confirm the association signals between SLE and TNIP1 variants in multiple populations and provide new insight into the mechanism by which TNIP2 and TAX1BP1 variants may contribute to SLE pathogenesis.