Claude Bouchard

TL;DR: In this article, a volume focused on the molecular and cellular regulation of adaptation to acute and chronic exercise exposure is presented, where the authors define the overall content of the "sedens-physical activity-exercise training-fitness" domain.

TL;DR: The DNASCO (DNA Polymorphism and Carotid Atherosclerosis) Study, a 6-year randomized, controlled trial in a population-based sample of middle-aged men, investigated the effect of regular long-term physical exercise on chronic low-grade inflammation and the progression of atherosclerosis, as assessed by noninvasive repeated measurements of carotid artery intimamedia thickness.

TL;DR: The results suggest that the associations between physical activity and body fat and plasma lipoprotein/lipid concentrations in men are dependent on the LIPE C-60G polymorphism, and highlight the importance of taking into account the role of gene-physical activity interactions in candidate gene studies of obesity and obesity-related traits.

TL;DR: Evidence of a gene-gene interaction in the regulation of plasma glucose-insulin homeostasis is provided, and these interactions need to be taken into account when dissecting the genetic etiology of complex disorders.

TL;DR: It is suggested that dietary fat intake may modify the effect of the FASN rs4246444 polymorphism on LDL-PPD, a small, dense LDL phenotype associated with an increased cardiovascular disease risk and a potential therapeutic target for obesity and insulin resistance.