Claude Bouchard

TL;DR: Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and case-control studies with candidate genes, and linkage studies with genes and other markers is reviewed.

TL;DR: This study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype and expresses the expression of the genotype effect is modulated by physical activity or cardiorespiratory fitness level.

TL;DR: It is concluded that a steroid profile characterized by high TESTO and low androgen metabolite levels accompanied the changes in body composition and body fat distribution generated by the exercise-induced negative energy balance.

TL;DR: A C‐1291G polymorphism in the α2A‐adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels.

TL;DR: With the completion of the sequencing of the human genome, the advances brought about by the International HapMap Project, and the progress in high-throughput genotyping technologies, bioinformatics, and statistical genetics, a more general approach was developed for the identification of genes with small effects on quantitative traits or disease state, known as genome-wide association studies or GWAS.