Claude Bouchard

TL;DR: The loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

TL;DR: This analysis provides a comprehensive map of the transcriptomic features important for aerobic exercise-induced improvements in maximal oxygen consumption and found that both the TRT and a homologous subset of the human high responder genes were regulated to a greater degree in high respondser rodent skeletal muscle.

TL;DR: Results of this study suggest that measurement of subscapular and abdominal fat should be considered when interpreting the blood lipid profile, particularly in males, because a higher percentage of fat must be present in women than in men to observe alterations in serum lipids.

TL;DR: Large-scale aptamer-based scanning of plasma proteins coupled with machine learning demonstrates proof-of-concept and feasibility of an individualized health check using a single blood sample and is anticipate that, with further validation and the addition of more protein-phenotype models, this approach could enable a single-source, individualized so-called liquid health check.

TL;DR: The three markers encompassing the UCP2 locus and spanning a 5 cM region on 11q13 are linked to resting energy expenditure in adult humans and the evidence is strong enough to warrant a search for DNA sequence variation in the gene itself.