C
Cornelia Sommer
Researcher at University of Graz
Publications - 9
Citations - 397
Cornelia Sommer is an academic researcher from University of Graz. The author has contributed to research in topics: Neurodegeneration & Apoptosis. The author has an hindex of 7, co-authored 8 publications receiving 326 citations. Previous affiliations of Cornelia Sommer include Free University of Berlin.
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Journal ArticleDOI
Spermidine protects against α-synuclein neurotoxicity
Sabrina Büttner,Filomena Broeskamp,Cornelia Sommer,Maria Markaki,Lukas Habernig,Ali Alavian-Ghavanini,Didac Carmona-Gutierrez,Tobias Eisenberg,Eva Michael,Guido Kroemer,Nektarios Tavernarakis,Stephan J. Sigrist,Frank Madeo +12 more
TL;DR: Administration of the naturally occurring polyamine spermidine alleviates a series of PD-related degenerative processes in the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, two established model systems for PD pathology.
Journal ArticleDOI
Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast
Ralf J. Braun,Ralf J. Braun,Cornelia Sommer,Didac Carmona-Gutierrez,Chamel Khoury,Julia Ring,Sabrina Büttner,Frank Madeo +7 more
TL;DR: It is demonstrated that mitochondria and oxidative stress are important to T DP-43-triggered cell death in yeast and may suggest a similar role in human TDP-43 pathologies.
Journal ArticleDOI
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona-Gutierrez,Andreas Zimmermann,Andreas Zimmermann,Katharina Kainz,Federico Pietrocola,Guo Chen,Silvia Maglioni,Alfonso Schiavi,Jihoon Nah,Sara Mertel,Christine B. Beuschel,Francesca Castoldi,Valentina Sica,Gert Trausinger,Reingard Raml,Cornelia Sommer,Sabrina Schroeder,Sebastian J. Hofer,Maria A. Bauer,Tobias Pendl,Jelena Tadic,Christopher Dammbrueck,Zehan Hu,Christoph Ruckenstuhl,Tobias Eisenberg,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Mahmoud Abdellatif,Simon Sedej,David Enot,David Enot,Heimo Wolinski,Jörn Dengjel,Oliver Kepp,Christoph Magnes,Frank Sinner,Frank Sinner,Thomas R. Pieber,Thomas R. Pieber,Junichi Sadoshima,Natascia Ventura,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +48 more
TL;DR: It is demonstrated that DMC extends lifespan and promotes health in multiple organisms by inducing autophagy and is identified in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine.
Journal ArticleDOI
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Ralf J. Braun,Cornelia Sommer,Christine Leibiger,Romina J.G. Gentier,Verónica I. Dumit,Katrin Paduch,Tobias Eisenberg,Lukas Habernig,Gert Trausinger,Christoph Magnes,Thomas R. Pieber,Thomas R. Pieber,Frank Sinner,Frank Sinner,Jörn Dengjel,Fred W. van Leeuwen,Guido Kroemer,Frank Madeo +17 more
TL;DR: It is shown that in brain regions of AD patients with neurofibrillary tangles UBB+1 co-exists with VMS1, the mitochondrion-specific component of the ubiquitin-proteasome system (UPS) and can be reversed by Cdc48/Vms1-mediated proteolysis.
Journal ArticleDOI
The metabolism beyond programmed cell death in yeast.
Julia Ring,Cornelia Sommer,Didac Carmona-Gutierrez,Christoph Ruckenstuhl,Tobias Eisenberg,Frank Madeo +5 more
TL;DR: Recent studies using the potential of the yeast model to provide new insights into the processes of stress defense, cell death and longevity are discussed.