C
Christine B. Beuschel
Researcher at Free University of Berlin
Publications - 10
Citations - 369
Christine B. Beuschel is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Synapse & Active zone. The author has an hindex of 6, co-authored 9 publications receiving 235 citations. Previous affiliations of Christine B. Beuschel include Charité.
Papers
More filters
Journal ArticleDOI
Rapid active zone remodeling consolidates presynaptic potentiation
Mathias A. Böhme,Anthony W. McCarthy,Andreas T. Grasskamp,Christine B. Beuschel,Pragya Goel,Meida Jusyte,Desiree Laber,Sheng Huang,Ulises Rey,Ulises Rey,Astrid G. Petzoldt,Martin Lehmann,Fabian Goettfert,Pejmun Haghighi,Stefan W. Hell,David Owald,Dion Dickman,Stephan J. Sigrist,Stephan J. Sigrist,Alexander M. Walter +19 more
TL;DR: Homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning are described.
Journal ArticleDOI
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona-Gutierrez,Andreas Zimmermann,Andreas Zimmermann,Katharina Kainz,Federico Pietrocola,Guo Chen,Silvia Maglioni,Alfonso Schiavi,Jihoon Nah,Sara Mertel,Christine B. Beuschel,Francesca Castoldi,Valentina Sica,Gert Trausinger,Reingard Raml,Cornelia Sommer,Sabrina Schroeder,Sebastian J. Hofer,Maria A. Bauer,Tobias Pendl,Jelena Tadic,Christopher Dammbrueck,Zehan Hu,Christoph Ruckenstuhl,Tobias Eisenberg,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Mahmoud Abdellatif,Simon Sedej,David Enot,David Enot,Heimo Wolinski,Jörn Dengjel,Oliver Kepp,Christoph Magnes,Frank Sinner,Frank Sinner,Thomas R. Pieber,Thomas R. Pieber,Junichi Sadoshima,Natascia Ventura,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +48 more
TL;DR: It is demonstrated that DMC extends lifespan and promotes health in multiple organisms by inducing autophagy and is identified in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine.
Journal ArticleDOI
Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release.
Varun K Gupta,Ulrike Pech,Anuradha Bhukel,Anuradha Bhukel,Andreas Fulterer,Andreas Fulterer,Anatoli Ender,Stephan F. Mauermann,Stephan F. Mauermann,Till F. M. Andlauer,Emmanuel Antwi-Adjei,Christine B. Beuschel,Kerstin Thriene,Marta Maglione,Marta Maglione,Christine Quentin,Christine Quentin,René Bushow,Martin Schwärzel,Thorsten Mielke,Frank Madeo,Joern Dengjel,André Fiala,Stephan J. Sigrist,Stephan J. Sigrist +24 more
TL;DR: It is shown that a specific synaptic compartment, the presynaptic active zone (AZ), increases the size of its ultrastructural elaboration and releases significantly more synaptic vesicles with advancing age, and age-induced AZ changes, however, were fully suppressed by spermidine feeding.
Journal ArticleDOI
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.
Anuradha Bhukel,Christine B. Beuschel,Christine B. Beuschel,Marta Maglione,Marta Maglione,Martin Lehmann,Gábor Juhász,Frank Madeo,Stephan J. Sigrist,Stephan J. Sigrist +9 more
TL;DR: It is shown that autophagy-regulated signaling emanating from a higher brain integration center can execute high-level control over other brain regions to steer life-strategy decisions such as whether or not to form memories.
Journal ArticleDOI
Presynaptic Active Zone Plasticity Encodes Sleep Need in Drosophila
Sheng Huang,Chengji Piao,Christine B. Beuschel,Torsten W.B. Götz,Stephan J. Sigrist,Stephan J. Sigrist +5 more
TL;DR: The results suggest that the presynaptic active zone plasticity driven by BRP operates as a sleep homeostatic actuator that also restricts periods of effective learning.