C
Cristina C. Rohena
Researcher at University of California, San Diego
Publications - 23
Citations - 491
Cristina C. Rohena is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 10, co-authored 23 publications receiving 408 citations. Previous affiliations of Cristina C. Rohena include University of Texas at San Antonio & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities
TL;DR: Recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubules-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes are covered.
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Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation.
Anel Lizcano,Ismael Secundino,Simon Döhrmann,Ross Corriden,Cristina C. Rohena,Sandra Diaz,Pradipta Ghosh,Lingquan Deng,Victor Nizet,Ajit Varki +9 more
TL;DR: It is proposed that a sialic acid-based "self-associated molecular pattern" on erythrocytes also helps maintain neutrophil quiescence in the bloodstream and help explain why neutrophils become easily activated after separation from whole blood.
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Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.
April L. Risinger,Jing Li,Melissa J. Bennett,Cristina C. Rohena,Jiangnan Peng,David C. Schriemer,Susan L. Mooberry +6 more
TL;DR: AJ imparts strong inter-protofilament stability in a manner different from other microtubule stabilizers that covalently bind to tubulin, consistent with the distinct effects of the taccalonolides as compared with other stabilizers.
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AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin
Nicolas Aznar,Arjun Patel,Cristina C. Rohena,Ying Dunkel,Linda P. Joosen,Vanessa Taupin,Irina Kufareva,Marilyn G. Farquhar,Pradipta Ghosh +8 more
TL;DR: A fundamental homeostatic mechanism by which the AMPK-GIV axis reinforces cell junctions against stress-induced collapse and also provides mechanistic insight into the tumor-suppressive action of Metformin is defined.
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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Xin Zhang,Sudhir Raghavan,Michael A. Ihnat,Jessica E. Thorpe,Bryan C. Disch,Anja Bastian,Lora C. Bailey-Downs,Nicholas F. Dybdal-Hargreaves,Cristina C. Rohena,Ernest Hamel,Susan L. Mooberry,Aleem Gangjee +11 more
TL;DR: In vivo, the HCl salt of 2,6-dimethylfuro[2,3-d]pyrimidines reduced tumor size and vascularity in xenograft and allograft murine models and was superior to docetaxel and sunitinib, without overt toxicity, thus affords potential combination chemotherapy in a single agent.